mRNA的差异剪接与神经系统发育

mRNA的选择性剪接可以使基因产生新的结构与功能,是基因表达调控的重要机制.神经系统中大部分的差异剪接基因与信号传导和调节有关,包括转录因子、受体、离子通道等,这些差异剪接影响细胞内基因的转录调控、信号传导、离子通道的动力学,从而对神经系统的发育、功能以及内环境的稳定性具有重要的调节作用.差异剪接的异常导致神经系统的疾病和肿瘤,因此可以作为治疗的靶标.

mRNA alternative splicing and nervous system development

mRNA alternative splicing is widely recognized to be a ubiquitous mechanism for controlling gene expression, through which genes can generate structural and functional diversities. The majority of alternative spliced genes in the nervous system were found to transmit and regulate signals, which include transcription factors, receptors and ion channels. Alternative splicing plays a pivotal role in development, function and ho-meostasis of the nervous system by affecting transcriptional regulation, signal transduction and ion channel dynamics. Errors in alternative splicing can cause neural disorders and cancers, and thus can be used as therapeutic targets.