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| 骨髓基质细胞与白血病细胞耐药、抗凋亡相关研究进展 | |
| 引用本文： | 李忠俊,陈幸华. 骨髓基质细胞与白血病细胞耐药、抗凋亡相关研究进展[J]. 中国实验血液学杂志, 2005, 13(3): 529-533 |
| 作者姓名： | 李忠俊 陈幸华 |
| 作者单位： | 第三军医大学附属新桥医院血液科,重庆,400037 |
| 摘 要： | 骨髓基质细胞与其分泌的细胞因子、细胞外基质构成的骨髓微环境在机体造血发育、血液病发生、恶性血液病细胞凋亡等生理病理过程中发挥着重要作用。本文综述了骨髓基质细胞保护白血病细胞抑制药物诱导的凋亡及其机制的相关研究进展。 |
| 关 键 词： | 白血病 细胞凋亡 骨髓基质细胞 |
| 文章编号： | 1009-2137(2005)03-0529-05 |
| 修稿时间： | 2004-06-28 |
Research Advances on Drug Resistance and Anti-apoptosis of Leukemic Cells Associated with Bone Marrow Stromal Cells--Review |
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| LI Zhong-jun,CHEN Xing-Hua. Research Advances on Drug Resistance and Anti-apoptosis of Leukemic Cells Associated with Bone Marrow Stromal Cells--Review[J]. Journal of experimental hematology, 2005, 13(3): 529-533 | |
| Authors: | LI Zhong-jun CHEN Xing-Hua |
| Affiliation: | Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China. |
| Abstract: | The bone marrow microenvironment composed of bone marrow cell, their secreted cytokines and extra-cellular medium (ECM), plays an important role in the process of hematopoiesis, hematonosis, apoptosis of malignant blood cells. In this review, the mechanisms for the protection of the leukemiic cells from the drug-induced apoptosis by bone marrow stromal cells and the related progress were summarized. |
| Keywords: | leukemia apoptosis bone marrow stromal cell |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |