Programmed Death-1 Gene Polymorphisms in Patients With Systemic Lupus Erythematosus in Taiwan |
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| Authors: | SHU-CHEN WANG YI-JING CHEN TSAN-TENG OU CHENG-CHIN WU WEN-CHAN TSAI HONG-WEN LIU JENG-HSIEN YEN |
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| Affiliation: | (1) Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;(2) College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;(3) Department of Internal Medicine, Kaohsiung Medical University Hospital, Division of Rheumatology, 100 Zihyou 1st Road, Kaohsiung City, 807, Taiwan;(4) Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan |
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| Abstract: | To investigate the role of programmed cell death-1 (PD-1) gene polymorphisms in the development of systemic lupus erythematosus (SLE) in Taiwan, 109 patients with SLE and 100 healthy controls were enrolled in this study. The PD-1 gene polymorphisms were determined by the method of polymerase chain reaction/restriction fragment length polymorphism. This study showed that the genotype distributions of PD-1 7209 C/T polymorphisms were significantly different between the patients with SLE and controls (P=0.002, Pc=0.018). The frequencies of the PD-1 7209 C/C genotype and PD-1 7209 C allele were significantly higher in the patients with SLE than those of the controls (P=0.001, OR=2.6, 95% CI=1.5–4.6, and P=0.002, OR=2.1, 95% CI=1.3–3.4, Pc=0.018, respectively). Moreover, the association of PD-1 7209 C with susceptibility to SLE was independent of the PD-1 ligand. This study also showed that the PD-1-536 A 7146 G 7209 C 7499 G haplotype was associated with the development of SLE in Taiwan.Both Authors Contributed equally to this work |
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| Keywords: | PD-1 systemic lupus erythematosus polymorphism haplotype |
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