小蓟化学成分的分离与鉴定

目的对传统中药小蓟的化学成分进行分离与鉴定,为进一步开发利用小蓟提供科学依据。方法采用反复硅胶柱色谱法进行分离纯化,通过理化常数测定和波谱分析鉴定其化学结构。结果从小蓟提取物的氯仿层和乙酸乙酯层中分离得到9个化合物,即苜蓿素(tricin,1)、蒙花苷(linarin,2)、咖啡酸(caffeic acid,3)、香豆酸(courmaric acid,4)、丁二酸(succinic acid,5)、芹菜素(apigenin,6)、苜蓿素-7-O-β-D-葡萄糖(tricin-7-O-β-D-glucopyranoside,7)、β-谷甾醇(β-sitosterol,8)、β-胡萝卜苷(β-daucosterol,9)。结论化合物5、7为首次从蓟属植物中分离得到,化合物1、4为首次从小蓟中分离得到。

Isolation and identification of chemical constituents from Cirsium setosum (Willd.) MB.

Abstract: Objective To isolate and identify the chemical constituents from Cirsium setosum (Willd.)MB. Mothods The compounds were isolated by chromatography on silica gel column and identified on the basis of physico-chemical constants and spectral analysis. Results Nine compounds were isolated and their structures were identified as tricin (1), linarin (2), caffeic acid (3), courmaric acid (4), succinic acid (5), apigenin (6), tricin-7-O-β-D-glucopyranoside (7), β-sitosterol (8) and β-daucosterol (9), respectively. Conclusions Compounds 5 and 7 are reported from this genus for the first time, compounds 1 and 4 are isolated from this plant firstly.