E—cadherin、nm23在甲状腺乳头状腺癌中的表达及其临床意义

目的：研究E－cadherin、nm23在甲状腺头状腺癌（papillary thyroid carcionma,PTC)中的表达及其临床意义。方法：应用免疫组化SP法，检测70例PTC中E－cadherin、nm23的表达。结果：E－cadherin、nm23的阳性表达率分别为44．3％（31／70），62．9％（44／70），分别与PTC的病理分级、TNM分期及淋巴结转移有关（P＜0．05），而与患者性别、年龄及肿瘤大小无明显的关系（P＞0．05；E－cadherin、nm23的表达具有高度的协同性；两者同时阳性表达的PTC，其淋巴结转移为12％（3／25），同时阴性表达的，其淋巴结转移为75％（15／20），两组之间有显著性差异（P＜0．01）。结论：E－cadherin、nm23在PTC浸润和转移方面存在相关性，可作为预测PTC生物学行为的标志 。

Expression of E-cadherin and nm23 in papillary thyroid carcinoma and its clinical significance

Purpose:To investigate the expression of E cadherin and nm23 in papillary thyroid carcinoma (PTC) and its clinical significance. Methods:The expression of E cadherin and nm23 were detected by SP immunohistochemical technique in 70 paraffin embedded tissue specimens of PTC.Results:The positive rates of E cadherin and nm23 were 44.3%(31/70) and 62.9%(44/70) respectively. There were close relations between the expression of E cadherin and nm23 and pathological grade, TNM stage and lymph node metastasis, and no difference could be found between the expression of E cadherin and nm23 and size of tumor, sex and age of patients. There was distinct correlation between the expression of E cadherin and nm23. The metastatic rate in the group, which the expression of E cadherin and nm23 were both positive, was 12%(3/25), but in the all negative group, the metastatic rate was 75%(15/20). There was significant difference between the two groups ( P <0.001). Conclusions:E cadherin and nm23 might play important roles in invasion and metastasis of PTC, and might be useful markers for evaluating the biological behavior of PTC. [