Functional localization of epileptic foci in cats using manganeseenhanced MRI

Objective： To determine the encephalic region correlated with epilepsy by manganese-enhanced MRI （MEMRI） and determine the correlation of epilepsy with calcium overloading. Methods： The cats were divided into two groups. The first group underwent EEG examination and ethological observation. The second group underwent MEMRI measurement. Signal enhanced encephalic regions were sectioned. Results： The achievement ratio of convulsive cats intramusclelarly injected with PTZ was 80%. MEMRI showed diffuse signal enhancement in the cerebral cortex of the cats with generalized tonic-clonic convulsive seizures compared with control animals. The enhancement rate of frontal-parietal-occipital lobe was 34.6% and 22.9% in temporl lobe compared with the control groups. Signal enhancement on frontal-parietal lobe persisted for 24 h after epileptic seizures were induced. The neurons of enhanced encephalic regions showed obvious degeneration and necrosis. Conclusion： Seizures can be induced in cats by intramuscular injection of PTZ （55 mg/kg）. Frontal-parietal lobe is the correlated encephalic regions of epilepsy. MEMRI plays an important role in localizing and revealing pathogenesis of epileptic seizures.

Functional localization of epileptic foci in cats using manganese-enhanced MRI

Objective:To determine the encephalic region correlated with epilepsy by manganese-enhanced MRI(MEMRI)and determine the correlation of epilepsy with calcium overloading.Methods:The cats were divided into two groups.The first group underwent EEG examination and ethological observation.The second group underwent MEMRI measurement.Signal enhanced encephalic regions were sectioned.Results:The achievement ratio of convulsive cats intramusclelarly injected with PTZ was 80%.MEMRI showed diffuse signal enhancement in the cerebral cortex of the cats with generalized tonic-clonic convulsive seizures compared with control animals.The enhancement rate of frontal-parietal-occipital lobe was 34.6% and 22.9% in temporal lobe compared with the control groups.Signal enhancement on frontal-parietal lobe persisted for 24 h after epileptic seizures were induced.The neurons of enhanced encephalic regions showed obvious degeneration and necrosis.Conclusion:Seizures can be induced in cats by intramuscular injection of PTZ(55 mg/kg).Frontal-parietal lobe is the correlated encephalic regions of epilepsy.MEMRI plays an important role in localizing and revealing pathogenesis of epileptic seizures.