乳腺癌患者外周血与肿瘤浸润淋巴细胞Fas表达的意义

目的　探讨 Fas受体与配体参与肿瘤与机体免疫系统相互作用的机制 .方法　用流式细胞仪对 2 1例乳腺癌患者外周血淋巴细胞 (PBL )与肿瘤浸润淋巴细胞 (TIL )的 Fas分子进行定性及定量分析 .结果　乳腺癌患者肿瘤浸润淋巴细胞的 Fas分子表达率为 0 .1 56,乳腺癌患者外周血淋巴细胞Fas分子表达率 0 .0 6,正常人外周血淋巴细胞 Fas分子表达率为 0 .1 1 4 ,前者明显高于后二者 (P<0 .0 5) ;乳腺癌患者外周血淋巴细胞的 Fas分子表达明显低于正常人外周血淋巴细胞 (P<0 .0 5) .结论　 Fas分子在乳腺癌患者外周血淋巴细胞与肿瘤浸润淋巴细胞的不同分布说明 :Fas不仅在肿瘤浸润区域 ,而且在全身参与了免疫系统与肿瘤的相互斗争

Fas expression on tumor infiltrating and peripheral blood lymphocytes in patients with breast cancer

AIM To research the role of Fas/Fas L in the mechanism of mutual action between tumor an immunological system. METHODS By two color flow cytometery, Fas expression on tumor infiltrating lymphocytes (TIL) and on matched peripheral blood lymphocytes (PBL) were detected in 21 cases of breast cancer (BC). RESULTS Expression rate of Fas on TIL was 0.156, on PBL of BC patients and normal healthy controls was 0.06 and 0.114 respectively. The former was significantly higher than the two latters ( P <0.05). CONCLUSION These different distributions of the Fas molecule suggest that Fas/Fas L pathway plays a major role in the fight between tumor and immunol system not only at tumor site but also at systemic level.