达英-35联合二甲双胍预治疗对多囊卵巢综合征患者早期流产的影响

目的:探讨药物预处理对接受IVF-ET的多囊卵巢综合征(PCOS)患者早期流产率的影响。方法:回顾性分析因输卵管因素接受IVF-ET获得临床妊娠的PCOS患者共116例。其中,30例患者进入周期前经达英-35单药治疗(A组),75例患者进入周期前经达英-35联合二甲双胍治疗(B组),均治疗3～6个周期;11例患者进入周期前不用药物治疗(C组)。比较3组患者进行IVF-ET后的早期流产率。结果:B组早期流产率显著低于A组及C组;A组早期胚胎流产率与C组比较无统计学差异。结论:IVF-ET周期前使用二甲双胍预处理能显著降低多囊卵巢综合征患者的早期流产率。

Effect of Preconditioning of Diane-35 Combined with Metformin on Reducing Early Miscarriage in Patients with Polycystic Ovary Syndrome

Objective： To evaluate the effect of different preconditioned treatments in polycystic ovary syndrome （PCOS） patients on decreasing the risk of early pregnancy loss after in vitro fertilization-embryo transfer （IVF-ET）. Methods： A total of 116 pregnant patients with PCOS and tubal factors after IVF cycle were retrospectively invested, of whom 30 had received preconditioned Diane-35 for 3-6 cycles （group A）, 75 had Diane-35 combined with metformin for 3-6 cycles （group B）, and 11 had no preconditioned treatment （group C）. The early miscarriage rates after IVF-ET cycle were compared among these three groups. Results： Group B had significant lower early abortion rate than group group A and group C. No difference of early abortion rate was found between group A and group C. Conclusion： Preconditioning of metformin can significantly decrease the risk of early pregnancy loss in patients with PCOS after IVF-ET.