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| 吡咯列酮对PCOS大鼠下丘脑、卵巢中瘦素受体表达的影响及其意义 | |
| 引用本文： | 王雪金,郑志群,苏艳华,徐惠贞. 吡咯列酮对PCOS大鼠下丘脑、卵巢中瘦素受体表达的影响及其意义[J]. 生殖与避孕, 2010, 30(6): 361-366,395 |
| 作者姓名： | 王雪金 郑志群 苏艳华 徐惠贞 |
| 作者单位： | 1. 福建医科大学附属第二医院妇产科,泉州,362000 2. 福建医科大学附属协和医院妇产科,福州,350001 |
| 摘 要： | 目的:研究吡咯列酮对PCOS大鼠下丘脑、卵巢中瘦素受体(Lep-R)表达的影响及其意义。方法:将30只雌性SD大鼠分为3组:正常对照组、PCOS组、吡咯列酮干预组。放射免疫法测定各组大鼠血清T、LH、空腹血清血糖(fasting serum glucose,FSG)、胰岛素(insulin,Ins)、瘦素(leptin,Lep)水平,通过免疫组织化学、实时荧光相对定量PCR(Real-time RT-PCR)方法检测各组大鼠下丘脑、卵巢中Lep-R的相对表达。结果:经吡咯列酮干预后,PCOS大鼠血清T、LH、Ins、Lep水平明显降低,下丘脑Lep-R表达增强,而卵巢中Lep-R表达减弱。结论:下丘脑Lep-R表达的下调可能是PCOS大鼠瘦素抵抗的原因之一;吡咯列酮可以改善PCOS大鼠内分泌紊乱。 |
| 关 键 词： | 多囊卵巢综合征(PCOS) 瘦素受体(Lep-R) 吡咯列酮 |
Influence of Pioglitazone to the Expression of Lep-R on the Hypothalamus and Ovaries of the Rats with Polycystic Ovary Syndrome |
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| Xue-jin WANG,Zhi-qun ZHENG,Yan-hua SU,Hui-zhen XU. Influence of Pioglitazone to the Expression of Lep-R on the Hypothalamus and Ovaries of the Rats with Polycystic Ovary Syndrome[J]. Reproduction and Contraception, 2010, 30(6): 361-366,395 | |
| Authors: | Xue-jin WANG Zhi-qun ZHENG Yan-hua SU Hui-zhen XU |
| Affiliation: | Xue-jin WANG1,Zhi-qun ZHENG2,Yan-hua SU2,Hui-zhen XU1(1.Department of Obstetrics and Gynecology,Second Affiliated Hospital of Fujian Medical University,Quanzhou,362000)(2.Department of Gynecology and Obstetrics,Union Hospital Affiliated to Fujian Medical University,Fuzhou,350001) |
| Abstract: | Objective:To study the influence of pioglitazone hydrochloride to the expression of leptin receptor(Lep-R) on the hypothalamus and ovaries of the rats with polycystic ovary syndrome.Metheds:Thirty female SD rats were divided into 3 groups:control group(group A),PCOS group(group B) and pioglitazone hydrochloride treated group(group C).The levels of serum T,LH,fasting serum glucose(FSG),Ins and Lep were measured by radioimmunology.The relative expression of Lep-R on the ovaries and hypothalamus of each group ... |
| Keywords: | polycystic ovary syndrome(PCOS) leptin receptor(Lep-R) pioglitazone hydrochloride |
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