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| 热敏型酸缓冲避孕凝胶剂的稳定性研究 | |
| 引用本文： | 田芳,李卫华,张燕,成倩倩,王玉柱,丁训诚. 热敏型酸缓冲避孕凝胶剂的稳定性研究[J]. 生殖与避孕, 2010, 30(5): 305-310,320 |
| 作者姓名： | 田芳 李卫华 张燕 成倩倩 王玉柱 丁训诚 |
| 作者单位： | 1. 上海市计划生育科学研究所,上海,200032;复旦大学公共卫生学院,上海,200032 2. 上海市计划生育科学研究所,上海,200032;同济大学附属同济医院妇产科,上海,200065 3. 上海市计划生育科学研究所,上海,200032 |
| 基金项目： | 卫生部科技重大专项课题 |
| 摘 要： | 目的:考察热敏型酸缓冲避孕凝胶(Ace-Acidgel)的稳定性。方法:酸碱滴定法测量热敏型酸缓冲避孕凝胶中冰醋酸的含量,分别于光照、低温、冻融和长期(12个月)留样条件下放置,于规定时间内,观察本品外观性状、pH、含量、黏度、胶凝温度及相变时间限度的变化。结果:本品外观性状、pH、含量、黏度、胶凝温度及相变时间限度在光照、低温、冻融和长期留样条件下基本无变化。结论:热敏型酸缓冲避孕凝胶稳定性较好,可在常温阴凉处保存。 |
| 关 键 词： | 避孕凝胶 冰醋酸 稳定性 |
Stability Study of Thermo-reversible Acid-buffering Contraceptive Gel |
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| Fang TIAN,Wei-hua LI,Yan ZHANG,Qian-qian CHENG,Yu-zhu WANG,Xun-cheng DING. Stability Study of Thermo-reversible Acid-buffering Contraceptive Gel[J]. Reproduction and Contraception, 2010, 30(5): 305-310,320 | |
| Authors: | Fang TIAN Wei-hua LI Yan ZHANG Qian-qian CHENG Yu-zhu WANG Xun-cheng DING |
| Affiliation: | 1.Shanghai Institute of Planned Parenthood Research,Shanghai,200032)(2.School of Public Health of Fudan University,Shanghai,200032)(3.Obstetrics and Gynecology Department,Tongji Hospital of Tongji University,Shanghai,200065) |
| Abstract: | Objective：To evaluate the stability of thermo-reversible acid-buffering contraceptive gel（Ace-Acid gel）.Methods：The content of glacial acetic acid content in Ace-Acid gel was measured using acid-based titration,and appearance,pH,content,viscosity,gelation temperature and phase-inversion time were examined under conditions of illumination,freezing/thawing and long-term preservation.Results：In the above-mentioned test conditions,appearance,pH,content,viscosity,gelation temperature and phase-inversion time of Ace-Acid gel samples did not change significantly.Conclusion：The Ace-Acid gel showed good stability,and can be preserved in room tempreture. |
| Keywords: | contraceptive gel glacial acetic acid stability |
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