磷酸化STAT3在非小细胞肺癌组织中的表达及其临床意义

目的:探讨磷酸化信号转导与转录激活因子3(pSTAT3)在非小细胞肺癌(NSCLC)中的表达及其与NSCLC各临床病理因素的关系。方法:采用免疫组织化学染色法检测59例NSCLC及其癌旁组织中pSTAT3的表达。结果:(1)NSCLC组织中,pSTAT3的表达明显高于癌旁组织(P<0.01);(2)pSTAT3的阳性表达与肿瘤组织的大小及NSCLC患者的吸烟状况有关,与性别、年龄、淋巴结转移、临床分期及组织分化程度无关。pSTAT3在腺癌中的阳性表达率较鳞癌高,但无统计学意义。结论:pSTAT3可能在肺癌的发生发展及指导靶向治疗中发挥重要作用。

Expression of pSTAT3 in non-small cell lung cancer and its clinical significance

AIM: To explore the expression of phosphorylated STAT3(pSTAT3) in non-small cell lung cancer(NSCLC) and its clinical significance.METHODS: The expression of pSTAT3 was detected in 59 cases of NSCLC and their para-cancerous tissue by immunohistochemical staining.RESULTS:(1) The expression of pSTAT3 in NSCLC was significantly higher than that in para-cancerous tissue.(2) The expression of pSTAT3 was associated with tumor’s size and smoking status,which was significantly higher in smaller tumors(diameter<3 cm) and nonsmokers than that in larger tumors(diameter≥3 cm) and smokers,but was not associated with gender,age,lymph node metastasis,clinical stage and differentiation grade.The percentage rate of pSTAT3 expression was higher in adenocarcinoma than that in squamous cell carcinoma but without statistically significant.CONCLUSION: pSTAT3 may play an important role in the development of NSCLC and the direction of targeted therapy.