| 吉西他滨固定剂量率静滴联合奥沙利铂治疗晚期胆道癌的临床研究 |
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| 引用本文： | 郑维锷,张武,原少斐,陈华,吴丽丽,陈文俊.吉西他滨固定剂量率静滴联合奥沙利铂治疗晚期胆道癌的临床研究[J].肿瘤学杂志,2011,17(11):854-856. |
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| 作者姓名： | 郑维锷 张武 原少斐 陈华 吴丽丽 陈文俊 |
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| 作者单位： | 温州医学院附属第三医院,浙江瑞安,325200 |
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| 摘 要： | 目的]评价吉西他滨固定剂量率静滴联合奥沙利铂（GEMOX方案）治疗晚期胆道癌的疗效和毒副作用。方法]47例晚期胆道癌患者均接受吉西他滨1 000mg/m2,10mg/（m2.min）静滴,d1、8;奥沙利铂130mg/m2,静脉滴注2h,d1;每3周重复。至少化疗3个周期。结果]47例患者均可评价疗效,无完全缓解病例,部分缓解9例（19.2%）,稳定22例（46.8%）,进展16例（34.0%）,总有效率（CR＋PR）为19.2%（9/47）。中位无进展生存期（PFS）4.7个月,中位总生存期（OS）9.3个月。主要毒副反应为中性粒细胞减少、血小板减少,恶心、呕吐,肝肾和外周神经毒性等。结论]吉西他滨固定剂量率静滴联合奥沙利铂治疗晚期胆道癌有效,但其血液学毒性需引起重视。
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| 关 键 词： | 胆道肿瘤 吉西他滨 固定剂量率 奥沙利铂 |
A Clinical Study of Fixed-dose Rate Gemcitabine Infusion Combined with Oxaliplatin in the Treatment for Patients with Advanced Biliary Tract Cancer |
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| ZHENG Wei-e,ZHANG Wu,YUAN Shao-fei,et al..A Clinical Study of Fixed-dose Rate Gemcitabine Infusion Combined with Oxaliplatin in the Treatment for Patients with Advanced Biliary Tract Cancer[J].Journal of Oncology,2011,17(11):854-856. |
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| Authors: | ZHENG Wei-e ZHANG Wu YUAN Shao-fei |
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| Institution: | ZHENG Wei-e,ZHANG Wu,YUAN Shao-fei,et al.(The Third Affiliated Hospital of Wenzhou Medical College,Wenzhou 325200,China) |
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| Abstract: | Purpose] To investigate the efficiency and toxicity of fixed-dose rate gemcitabine combined with oxaliplatin in the treatment for patients with advanced biliary tract cancer(BTC).Methods] Forty-seven cases with advanced BTC received the combination of gemcitabine and oxaliplatin(GEMOX regimen,gemcitabine at the dose of 1 000mg/m 2,10mg/(m 2.min) intravenous infusion,d 1,8;oxaliplatin at 130mg/m 2 intravenous drip 2h on d 1.Every 3 weeks as a cycle,and the patients received at least 3 cycles.Results] All ... |
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| Keywords: | biliary tract neoplasms gemcitabine fixed-dose rate oxaliplatin |
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