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| FOLFOX4与FLP方案在食管胃结合部癌辅助化疗中的疗效比较 | |
| 引用本文： | 杨子鑫,王龙,王玉栋,左静,刘巍,王淑琴,王玉华,刘凤玲,魏素菊. FOLFOX4与FLP方案在食管胃结合部癌辅助化疗中的疗效比较[J]. 肿瘤, 2011, 0(9): 851-855. DOI: 10.3781/j.issn.1000-7431.2011.09.014 |
| 作者姓名： | 杨子鑫 王龙 王玉栋 左静 刘巍 王淑琴 王玉华 刘凤玲 魏素菊 |
| 作者单位： | 河北医科大学第四医院肿瘤内科,石家庄,050011 |
| 摘 要： | 目的:回顾性分析辅助化疗FOLFOX4方案与FLP方案治疗食管胃结合部癌根治术后患者的疗效和不良反应。方法:回顾性分析2007年3月-2009年10月共123例接受FOLFOX4方案(67例)或FLP方案(56例)辅助化疗的食管胃结合部癌根治术后患者。主要评价指标为无病生存期(disease-free survival,DFS)、总生存期(overall survival,OS)和不良反应。同时,对两组患者的疗效进行分层分析。结果:FOLFOX4方案组和FLP方案组的中位DFS分别为35.9和16.8个月(P=0.008),中位OS分别为41.3和25.6个月(P=0.013)。分层分析显示,男性、45～65岁、腺癌以及Ⅱ期或ⅢA期患者接受FOLFOX4方案术后辅助化疗较FLP方案更具生存优势。FOLFOX4和FLP方案均耐受良好,血液学不良反应发生率无明显差异。FOLFOX4方案组非血液学不良反应主要为外周神经毒性,FLP方案组主要为消化系统反应。结论:与FLP方案相比,FOLFOX4方案辅助化疗可明显延长食管胃结合部癌术后患者的DFS和OS,且不良反应可耐受。 |
| 关 键 词： | 癌,食管胃结合处 抗肿瘤联合化疗方案 辅助化疗 FOLFOX4方案 FLP方案 |
Comparison of efhcacy between FOLFOX4 regimen and FLP regimen as adjuvant chemotherapy for carcinoma of esophagogastric junction |
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| YANG Zi-xin,WANG Long,WANG Yu-dong,ZUO Jing,LIU Wei,WANG Shu-qin,WANG Yu-hua,Liu Feng-ling,Wei Suo-ju. Comparison of efhcacy between FOLFOX4 regimen and FLP regimen as adjuvant chemotherapy for carcinoma of esophagogastric junction[J]. Tumor, 2011, 0(9): 851-855. DOI: 10.3781/j.issn.1000-7431.2011.09.014 | |
| Authors: | YANG Zi-xin WANG Long WANG Yu-dong ZUO Jing LIU Wei WANG Shu-qin WANG Yu-hua Liu Feng-ling Wei Suo-ju |
| Affiliation: | YANG Zi-xin,WANG Long,WANG Yu-dong,ZUO Jing,LIU Wei,WANG Shu-qin,WANG Yu-hua,LIU Feng-ling,WEI Su-ju Department of Medical Oncology,Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China |
| Abstract: | Objective:To retrospectively analyze the efficacy and toxicity of 5-fluorouracil/leucovorin(5-Fu/LV) plus oxaliplatin(FOLFOX4) versus 5-Fu/LV plus cisplatin(FLP) as adjuvant chemotherapy for carcinoma of esophagogastric junction(CEGJ).Methods:The clinical information of one hundred and twenty-three patients with CEGJ who had accepted radical operation was collected from March 2007 to October 2009.These patients received either FOLFOX4 regimen(n = 67) or FLP regimen(n = 56).The major measurements were diseas... |
| Keywords: | Carcinoma esophagogastric junction Antineoplastic combined chemotherapy protocols Adjuvant chemotherapy FOLFOX4 regimen FLP regimen |
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