| Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants |
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| 作者姓名： | Vincent Lai David Mutimer Darius Mirza |
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| 作者单位： | Department of Liver Surgery，Department of Liver Surgery，Department of Liver Surgery Queen Elizabeth Hospital Birmingham B15 2TH UK Queen Elizabeth Hospital Birmingham B15 2TH UK Queen Elizabeth Hospital Birmingham B15 2TH UK |
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| 摘 要： | BACKGROUND: The recurrence of chronic hepatitis B after liver transplantation results in increased risk for graft failure and death of patients. Lamivudine has been shown to be effective in the treatment of chronic hepatitis B, but resistance to this agent is common after prolonged administration. METHODS: One patient with chronic hepatitis B virus (HBV) infection developed resistance to lamivudine after 15 months of treatment. The resistance was confirmed by mutation in the HBV DNA polymerase gene. The patient was treated subsequently with adefovir dipivoxil for 7 months. RESULT: HBV DNA and HBsAg were tested negative, but HBeAb and HBsAb were positive. CONCLUSION: This study provides an evidence that adefovir dipivoxil can be effective in the treatment of lamivudine-resistant HBV mutants.
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Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants |
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| Vincent Lai,David Mutimer,Darius Mirza.Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants[J].国际肝胆胰疾病杂志,2006(1). |
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| Authors: | Wan-Xing Zhang Vincent Lai David Mutimer and Darius Mirza |
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| Institution: | Wan-Xing Zhang,Vincent Lai,David Mutimer and Darius Mirza Department of Liver Surgery,Hebei Province People's Hospital,Shijiazhuang 050051,China Department of Liver Surgery,Queen Elizabeth Hospital,Birmingham,B15 2TH,UK |
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| Abstract: | BACKGROUND: The recurrence of chronic hepatitis B after liver transplantation results in increased risk for graft failure and death of patients. Lamivudine has been shown to be effective in the treatment of chronic hepatitis B, but resistance to this agent is common after prolonged administration. METHODS: One patient with chronic hepatitis B virus (HBV) infection developed resistance to lamivudine after 15 months of treatment. The resistance was confirmed by mutation in the HBV DNA polymerase gene. The patient was treated subsequently with adefovir dipivoxil for 7 months. RESULT: HBV DNA and HBsAg were tested negative, but HBeAb and HBsAb were positive. CONCLUSION: This study provides an evidence that adefovir dipivoxil can be effective in the treatment of lamivudine-resistant HBV mutants. |
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| Keywords: | adefovir dipivoxil hepatitis B virus liver transplantation lamivudine |
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