NT—proBNP在心功能不全诊治中的临床意义

目的探讨NT—proBNP用于心功能不全诊断的临床意义。方法回顾性分析我院2011年1月-2012年12月收治心功能不全患者290例心功能分级，左心室射血分数（LVEF）及血浆NT-proBNP水平等临床资料。结果心功能分级Ⅰ级、Ⅱ级、Ⅲ1级及Ⅳ级者NT—proBNP水平分别为（134．5±27．0）pg／ml，（495．2±132．4）pg／ml，（1344．8±315．9）pg／ml，（1602．7±398．3）pg／ml；LVEF水平分别为（68．1±12．3）％，（60．8±11．4）％，（54．5±13．3）％，（46．2±9．7）％；其中血浆NT—proBNP水平〈100pg／ml者约占总人数12．8％，而LVEF水平〉50％者约占总数65．5％。结论NT—proBNP用于心功能不全诊断有助于降低临床漏诊率；其水平与心功能分级呈正相关，与LVEF水平呈负相关。

Clinical value of NT-proBNP in diagnosis and treatment of ventricniar dysfunction

Objective To investigate the clinical value of N-terminal prohormone of brain natriuretic peptide （NT- proBNP） in the diagnosis and treatment of ventricular dysfunction. Methods A retrospective analysis was performed on the clinical data of 290 patients with ventricular dysfunction who were admitted to our hospital from January 2011 to December 2012, including plasma NT-proBNP level, cardiac functional grades, and left ventricular ejection fraction （LVEF） Results The NT- proBNP levels of patients whose cardiac functional grades were Ⅰ,Ⅱ, Ⅲ, and Ⅳwere 134.5±27.0 pg/ml, 495.2±132.4 pg/ ml, 1344.8±315.9 pg/ml, and 1602.7±398.3 pg/ml, respectively; LVEF levels were 68.1±12.3%, 60.8±11.4%, 54.5± 13.3%, and 46.2±9.7%, respectively. The patients whose plasma NT-proBNP levels were lower than 100 pg/ml and whose LVEF levels were higher than 50% accounted for 12.8% and 65.5%, respectively. Conclusion The application of NT-proBNP in diagnosis and treatment of ventricular dysfunction can help to reduce the clinical misdiagnosis rate; NT- proBNP level is positively correlated with cardiac functional grade but negatively correlated with LVEF level.