Chromosome anomalies as predictors of recurrence risk for spontaneous abortion |
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Authors: | N E Morton D Chiu C Holland P A Jacobs D Pettay |
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Affiliation: | Memorial Sloan-Kettering Cancer Center, New York, NY 10021. |
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Abstract: | Reproductive histories and chromosomes of spontaneous abortions were studied by segregation analysis in 1890 sibships ascertained through a cytogenetically studied abortion. Normal karyotypes are associated with recurrent abortion. Among abnormal karyotypes, trisomy has an elevated recurrence risk even after adjustment through a liability indicator for maternal age. Possible mechanisms and conflicting evidence in the literature on trisomy are discussed. None of these differences in recurrence risk is large enough to play a significant numerical role in genetic counseling. |
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