| 红豆杉提取物中紫杉醇的反相高效液相色谱法测定 |
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| 引用本文： | 徐礼桑,刘爱茹. 红豆杉提取物中紫杉醇的反相高效液相色谱法测定[J]. 药学学报, 1989, 24(7): 552-555 |
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| 作者姓名： | 徐礼桑 刘爱茹 |
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| 作者单位： | 中国医学科学院药物研究所，中国医学科学院药物研究所 北京 100050，北京 100050 |
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| 摘 要： | 本文报道应用反相高效液相色谱法测定红豆杉提取物中紫杉醇的含量,以倍他米松作内标,在填充以10μm LiChrosorb RP-18固定相的250×4mm不锈钢柱上以甲醇-水(30:10v/v)作流动相。228 nm处检测。本法简便、快速、准确,适用于微量样品的测定。
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| 关 键 词： | 紫杉醇 红豆杉 高效液相色谱法 |
| 收稿时间： | 1988-04-21 |
DETERMINATION OF TAXOL IN THE EXTRACT OF TAXUS CHINENSIS BY REVERSED PHASE HPLC |
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| LX Xu and AR Liu. DETERMINATION OF TAXOL IN THE EXTRACT OF TAXUS CHINENSIS BY REVERSED PHASE HPLC[J]. Acta pharmaceutica Sinica, 1989, 24(7): 552-555 |
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| Authors: | LX Xu and AR Liu |
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| Abstract: | Taxol, isolated from the stem bark of the plant Taxus chinensis, is a compound with a taxane ring~(1, 2) and is different from the known anticancer drugs in chemical structure. Taxol showed significant antineoplastic effect on transplantable tumors in mice.Because the antineoplastic effectis related to the content of taxol, a simple method is needed for the determination of taxol in the extract of Taxus chinensis samples.In this paper, an HPLC method for the determination of taxol is described in which betamethasone is used as an internal standard. The method is simple, rapid and accurate, as little as 0.1μg of taxol can be measured. |
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| Keywords: | Taxoi Taxus chinensis HPLC |
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