航空性中耳炎的实验研究

目的：建立航空性中耳炎的动物研究模型。方法：选用健康豚鼠30只，由左鼻腔放聚氯乙烯（PVC）管直至鼻咽部7d，在放PVC管前、后和治疗后分别进行低压舱试验，每次低压舱试验前后均观察鼓膜及鼓室图变化。结果：①放PVC管后CT显示鼻腔、鼻窦和鼻咽部炎性改变，治疗后炎性消退。②放PVC管后分别与放PVC管前、治疗后比较，左耳鼓膜和鼓室图变化差异有统计学意义。放PVC管后左耳与右耳相比，鼓膜和鼓室图变化差异有统计学意义。结论：建立的航空性中耳炎研究模型对临床诊断、分类、治疗和健康鉴定有一定的指导意义。

Experimental study of aero-otitis media

OBJECTIVE: To establish the animal model of aero-otitis media. METHOD: Thirty healthy guinea-pigs were selected and PVC tube was placed from left nasal cavity to nasopharynx for 7 days. Hyopbaric chamber experiment was performed before and after tube placement, and also after the treatment. Eardrum examination and tympanogram were carried out each time before and after the hyopbaric chamber experiment. RESULT: (1)The inflammation of nasal cavity, nasal sinuses and nasopharynx could be seen on CT after PVC tube placement. After treatment, the inflammation subsidised. (2) There was significant difference in left eardrum and tympanogram before and after tube placement, as well as after tube placement and after treatment. Significant difference could also be seen between left ear and right ear after the tube placement. CONCLUSION: The animal model in this study may provide reference in diagnosis, classification, treatment and health evaluation of earo-otitis media in pilots.