丹红注射液对冠状动脉慢血流现象的疗效观察

目的:观察丹红注射液治疗冠状动脉慢血流现象(CSFP)的临床疗效,探讨丹红注射液改善冠脉微循环障碍的可能机制。方法:64例冠脉造影有CSFP及运动负荷试验阳性患者,随机分为观察组(n=32)和对照组(n=32)进行治疗,对照组给予常规药物,观察组在对照组治疗基础上加用丹红注射液。治疗10天后,观察两组临床疗效及血清内皮素-1(ET-1)、血栓调节蛋白(TM)及超敏C-反应蛋白(hs-CRP)水平变化。结果:治疗前,两组各项观察指标差异无统计学意义(P0.05)。治疗10天后,观察组心绞痛缓解总有效率、心电图改善总有效率及运动负荷试验的运动总时间及运动至ST段压低0.1mV的时间均明显高于对照组(90.62%vs 68.75%、84.37%vs 59.37%、441.06±50.61svs 405.03±49.25s、304.53±43.24svs 260.53±49.02s)(P0.01);两组患者治疗后的血清ET-1、TM、hs-CRP水平均较同组治疗前显著降低(P0.01),观察组各项指标较对照组下降更明显(P0.01)。结论:丹红注射液可通过改善血管内皮功能及减轻炎症反应,有效治疗CSFP。

Treatment of Coronary Slow Flow Phenomenon with Danhong Inj ection

Objective：To investigate the clinical efficacy of Danhong injection treatment of coronary slow flow phenomenon （CSFP）,and to explore the possible mechanism of Danhong injection to improve coronary microcirculation.Method： Coronary angiography of coronary slow flow phenomenon and found that 64 patients with positive exercise stress test were randomly divided into observation group （n =32）and control group （n =32）,patiens in control group were given conventional treatment,while those in observation group were given Danhong injection on the basis of conventional treatment.All patients were treated for 10 days,before and after treatment the changes in clinical efficacy and measurement of blood endothelin-1 （ET-1）,thrombomodulin （TM）and c-reactive protein （hs-CRP）levels were observed.Results：Before treatment,all the observation indexes were no statistically significant difference between the two groups （P 〉0.05）.After treatment for 10 days,the two groups were compared with the observation group improvement of angina extent and ECG and exercise stress test parameters were better than the control group, the differences were statistically significant （P 〈0.05）.Serum ET-1,TM,hs-CRP levels compared with the observation group significantly lower in the control group,the differences were statistically significant （P 〈0.01）.Conclusion： Danhong injection can improve blood flow in patients with coronary slow clinical symptoms,improve vascular endothelial function disorder and reduce the degree of inflammation.