| 胃肠道间质瘤45例临床病理分析 |
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| 引用本文： | 张润岐,姜风良,阎爱丽,李政委,宋福合,吴庚利. 胃肠道间质瘤45例临床病理分析[J]. 医学争鸣, 2006, 27(14): 1322-1324 |
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| 作者姓名： | 张润岐 姜风良 阎爱丽 李政委 宋福合 吴庚利 |
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| 作者单位： | 西安医学院病理学教研室,陕西,西安,710068;陕西省友谊医院病理科,陕西,西安,710068 |
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| 摘 要： | 目的:探讨胃肠道间质瘤(GIST)的临床病理、免疫组织化学特点. 方法:对45例发生在胃肠道的间质瘤行常规检查及免疫组织化学染色,进行观察和对比分析. 结果:GIST的肿瘤细胞较经典的平滑肌瘤更加丰富,胞质嗜酸性较弱,瘤细胞为梭形或上皮样,或梭形与上皮样细胞混合存在,胞质内常见空泡形成,排列成交织束状、弥漫片状、栅栏状或轮辐状,有较为特征的细胞团巢形成. 间质或血管壁玻璃样变性. 结论:GIST有较为独特的组织形态学特点,CD117和CD34联合应用有助于鉴别诊断.
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| 关 键 词： | 胃肠肿瘤 间皮瘤 病理形态学 免疫组织化学 诊断 鉴别 |
| 文章编号： | 1000-2790(2006)14-1322-03 |
| 收稿时间： | 2006-03-02 |
| 修稿时间： | 2006-04-30 |
Clinicopathological analysis of 45 cases of gastrointestinal stromal tumor |
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| ZHANG Run-Qi,JIANG Feng-Liang,YAN Ai-Li,LI Zheng-Wei,SONG Fu-He,WU Geng-Li. Clinicopathological analysis of 45 cases of gastrointestinal stromal tumor[J]. Negative, 2006, 27(14): 1322-1324 |
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| Authors: | ZHANG Run-Qi JIANG Feng-Liang YAN Ai-Li LI Zheng-Wei SONG Fu-He WU Geng-Li |
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| Abstract: | AIM: To explore the clinicopathology of gastrointestinal stromal tumor(GIST)and its immunohistochemical features. METHODS: Observation and contrast analysis were made after the routine check and immunohistochemical staining in 45 GIST cases. RESULTS: GIST cells were more abundant than the typical leiomyoma cells and presented spindle-shaped or epithelioid, or a coexistence of spindle-shaped or epithelioid cells; in cytoplasm, the acidophilia decreased, and vacuoles were found arranged like intertexture, widespread lamellar, palisade or wheel radiation;typical cell nesting was formed;stroma or vessel wall showed a hyaline degeneration. CONCLUSION: GIST possesses unique histomorphological characteristics and the combination of CD117 and CD34 was helpful to differential diagnosis. |
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| Keywords: | gastrointestinal neoplasms mesothelioma pathomorphology immunohistochemistry diagnosis,differential |
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