Allergic sensitization pattern of patients in Brazil |
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Authors: | Carolina Sanchez Aranda Renata R Cocco Felipe F Pierotti Emanuel Sarinho Flávio Sano Arnaldo Porto Nelson Rosário Herberto J Chong Neto Ekaterini Goudouris Lillian S Moraes Neusa F Wandalsen Marcia C Mallozi Antônio C Pastorino Jackeline M Franco Maria L Chavarria Magnus Borres Dirceu Solé |
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Institution: | 1. Universidade Federal de São Paulo, Departamento de Pediatria, São Paulo, SP, Brazil;2. Universidade Federal de Pernambuco, Departamento de Pediatria, Recife, PE, Brazil;3. Hospital Nipo Brasileiro, Departamento de Pediatria, São Paulo, SP, Brazil;4. Universidade de Passo Fundo, Departamento de Pediatria, Passo Fundo, RS, Brazil;5. Universidade Federal do Paraná, Departamento de Pediatria, Curitiba, PR, Brazil;6. Universidade Federal do Rio de Janeiro, Departamento de Pediatria, Rio de Janeiro, RJ, Brazil;7. Universidade Federal de Mato Grosso, Departamento de Pediatria, Cuiabá, MT, Brazil;8. Faculdade de Medicina do ABC, Departamento de Pediatria, São Paulo, SP, Brazil;9. Universidade de São Paulo, Departamento de Pediatria, São Paulo, SP, Brazil;10. Universidade Federal de Sergipe, Departamento de Pediatria, Aracaju, SE, Brazil;11. Universidade Federal de Goiás, Departamento de Pediatria, Goiânia, GO, Brazil;12. Uppsala University, Department of Maternal and Child Health, Uppsala, Sweden |
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Abstract: | ObjectiveAllergic sensitization is one of the key components for the development of allergies. Polysensitization seems to be related to the persistence and severity of allergic diseases. Furthermore, allergic sensitization has a predictive role in the development of allergies. The aim of this study was to characterize the pattern of sensitization of atopic patients treated at different pediatric allergy referral centers in Brazil.MethodsA nation-wide transversal multicenter study collected data on patients attended in Brazil. Peripheral blood samples were collected to determine the serum levels of allergen-specific IgE. If allergen-specific IgE was higher than 0.1 kUA/L, the following specific components were quantified.ResultsA total of 470 individuals were enrolled in the study. Mite sensitization was the most frequent kind in all participants. A high frequency of sensitization to furry animals and grasses featured in the respiratory allergies. Regarding components, there was a predominance of sensitization to Der p 1 and Der p 2. It has been verified that having a food allergy, atopic dermatitis, or multimorbidity are risk factors for the development of more severe allergic disease.ConclusionStudies on the pattern of allergic sensitization to a specific population offer tools for the more effectual prevention, diagnosis, and treatment of allergic diseases. Sensitization to dust mites house was the most prevalent in the evaluated sample. High rates of sensitization to furry animals also stand out. Patients with food allergy, atopic dermatitis, or multimorbidity appear to be at greater risk for developing more severe allergic diseases. |
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Keywords: | Allergy Sensitization Children Biomarkers Prognosis |
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