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Interleukin 33 Triggers Early Eosinophil-Dependent Events Leading to Metaplasia in a Chronic Model of Gastritis-Prone Mice
Authors:Carlo De Salvo  Luca Pastorelli  Christine P Petersen  Ludovica F Buttò  Kristine-Ann Buela  Sara Omenetti  Silviu A Locovei  Shuvra Ray  Hannah R Friedman  Jacob Duijser  Wei Xin  Abdullah Osme  Fabio Cominelli  Ganapati H Mahabeleshwar  Jason C Mills  James R Goldenring  Theresa T Pizarro
Institution:1. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio;2. Gastroenterology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese, Milan, Italy;3. Department of Biomedical Sciences for Health, University of Milan, Milan, Italy;4. Department of Surgery and the Epithelial Biology Center, Vanderbilt University, Nashville, Tennessee;5. Division of Gastroenterology & Liver Disease, Department Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio;6. Gastroenterology Division, Department of Medicine, Washington University in St. Louis School of Medicine, St Louis, Missouri;1. Department of Interventional Radiology, Westmead Hospital, Westmead, NSW, Australia;2. Department of Gastroenterology, Royal Melbourne Hospital, Parkville, VIC, Australia;3. Department of Tissue Pathology and Diagnostic Oncology, Institute of Cellular Pathology and Molecular Research, Westmead Hospital, Westmead, NSW, Australia
Abstract:
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  • Keywords:IL-33/ST2 Axis  M2 Macrophages  SPEM/Intestinalized SPEM  Gastric Cancer  Apc"}  {"#name":"keyword"  "$":{"id":"kwrd0035"}  "$$":[{"#name":"text"  "_":"adenomatous polyposis coli  BM"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"bone marrow  BrdU"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"5-bromo-2-deoxyuridine  CCR3"}  {"#name":"keyword"  "$":{"id":"kwrd0065"}  "$$":[{"#name":"text"  "_":"C-C motif chemokine receptor 3  CD"}  {"#name":"keyword"  "$":{"id":"kwrd0075"}  "$$":[{"#name":"text"  "_":"cluster of differentiation  Clu"}  {"#name":"keyword"  "$":{"id":"kwrd0085"}  "$$":[{"#name":"text"  "_":"clusterin  Fc"}  {"#name":"keyword"  "$":{"id":"kwrd0095"}  "$$":[{"#name":"text"  "_":"fragment crystallizable  fIL33"}  {"#name":"keyword"  "$":{"id":"kwrd0105"}  "$$":[{"#name":"text"  "_":"full-length interleukin 33  GIF"}  {"#name":"keyword"  "$":{"id":"kwrd0115"}  "$$":[{"#name":"text"  "_":"gastric intrinsic factor  GSII"}  {"#name":"keyword"  "$":{"id":"kwrd0125"}  "$$":[{"#name":"text"  "$$":[{"#name":"italic"  "_":"Griffonia simplicifolia"}  {"#name":"__text__"  "_":" lectin II  IL"}  {"#name":"keyword"  "$":{"id":"kwrd0145"}  "$$":[{"#name":"text"  "_":"interleukin  ILC2"}  {"#name":"keyword"  "$":{"id":"kwrd0155"}  "$$":[{"#name":"text"  "_":"type 2 innate lymphoid cells  Il1rl1"}  {"#name":"keyword"  "$":{"id":"kwrd0165"}  "$$":[{"#name":"text"  "_":"interleukin-1 receptor-like 1  LP"}  {"#name":"keyword"  "$":{"id":"kwrd0175"}  "$$":[{"#name":"text"  "_":"lamina propria  MBP"}  {"#name":"keyword"  "$":{"id":"kwrd0185"}  "$$":[{"#name":"text"  "_":"major basic protein  PAS"}  {"#name":"keyword"  "$":{"id":"kwrd0195"}  "$$":[{"#name":"text"  "_":"periodic acid–Schiff  PFA"}  {"#name":"keyword"  "$":{"id":"kwrd0205"}  "$$":[{"#name":"text"  "_":"paraformaldehyde  qPCR"}  {"#name":"keyword"  "$":{"id":"kwrd0215"}  "$$":[{"#name":"text"  "_":"quantitative polymerase chain reaction  rIL33"}  {"#name":"keyword"  "$":{"id":"kwrd0225"}  "$$":[{"#name":"text"  "_":"recombinant interleukin 33  SAMP"}  {"#name":"keyword"  "$":{"id":"kwrd0235"}  "$$":[{"#name":"text"  "_":"SAMP1/YitFc  SPEM"}  {"#name":"keyword"  "$":{"id":"kwrd0245"}  "$$":[{"#name":"text"  "_":"spasmolytic polypeptide-expressing metaplasia  TFF1/2"}  {"#name":"keyword"  "$":{"id":"kwrd0255"}  "$$":[{"#name":"text"  "_":"trefoil factor 1/2
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