AAT异质体对AFP阴性肝癌的诊断价值

目的：探讨AAT异质体对AFP阴性肝癌的诊断价值。方法：采用豌豆凝集素亲和交叉免疫电泳法，检测78例原发性肝癌（21例AFP≤20μ／L）、20例慢性肝病及29例正常对照的血清AAT异质体。数据处理用配对资料t检验及x2检验。结果：肝癌组AAT-RP百分比显著高于慢性肝病组及对照组（P＜0.05）。AFP≤20μg／L与AFP＞20μg／L肝癌患者之AAT-RP的百分比差异大显著性（P＞0.05）。AAT—RP对肝癌的敏感性为66.67％、特异性为75.00／、阳性预测值高达91.23％。对AFP≤20μg／L及AFP＞20μg／L肝癌的敏感性、特异性、阳性预测值均差异无显著性（P＞0.05）。结论;无论AFP浓度是否升高，检测AAT异质体都有助于肝癌的临床诊断。

Role of AAT Variant in the Diagnosis of HCC with Negative AFP

Purpose: To assess the diagnostic value of alpha-1-antitrypsin variant in HCC with negative AFP. Method: The detection of serum AAT variant was performed by PSA-ClAE in 78 cases of HCC (21 with negative AFP), and 20 cases of chronic liver disorders and 29 cases of control. The data were analyzed by t and X2 teat. Results: The percentages of AAT variant in HCC were sigaificantly higher Than those in CLD and normal control. The percentages and positive rate of AAT variant in HCC of normal concentration AFP were as similar as those of abnormal concentration AFP. In patients with HCC, the sensitivity, specificit37 and positive predictive vaiuc of AAT variant were 66. 67 58, 75. 00 % and 91. 23 % respectively. The sensitivit:; specificity and positive predictive value of AAT varlant in HCC of normal concentration AFP were as similar as those of abn0rmal concentration AFP. Conclusion: The measurement of serum AAT variant is helpful to the diagnosis of HCC, especially when serum concentration of AFP is within normal ranges.