肝硬化患者肝组织质量与可溶性细胞间粘附分子1含量的关系

目的探讨代偿期肝硬化患者肝组织质量与肝血流动力学、可溶性细胞间粘附分子1含量的关系。方法分别用彩超、放射免疫法及病理HE染色法检查100例代偿期肝硬化患者．研究肝组织质量与肝血流动力学、肝纤维化指标及病理分期的关系。结果肝硬化患者肝质量越重，病理肝纤维化程度越明显，并随着肝质量的增加，肝血流减少；肝硬化患者肝组织不同质量的透明质酸（HA）、Ⅲ型前胶原（HPCⅢ）和血清Ⅳ型胶原（CⅣ）含量明显高于正常对照组（P〈0．05）；肝组织质量越重，血清HA、HPCⅢ和CⅣ含量越高；肝硬化患者肝组织质量与血清肝纤维化程度呈正相关（r=0．5612，P〈0．05）。结论肝硬化患者肝组织质量与肝血流动力学、肝纤维化指标及病理分期有关。

Relationship between liver mass and soluble intercellular adhesion molecule-1 in patients with liver cirrhosis

OBJECTIVE: To investigate the relation of liver mass to, liver hymodynamics and soluble intercellular adhesion molecule-1 in patients with liver cirrhosis. METHODS: The liver mass was measured by liver biopsy, hepatic hemodynamics by ultrasonography, and the contents of hyalurionic acid (HA), human procollagen III (HPC III) and collagen type IV (C IV) by radioimmunoassay in 100 patients with liver cirrhosis in compensation stage and 30 normal control subjects. RESULTS: Greater liver mass was accompanied by more severe liver fibrosis and reduced liver blood flow. The contents of HA, HPC III and C IV were obvious higher in the patients than in the normal controls (P<0.05) and increased with the liver mass. The liver mass was positively related to serum liver fibrosis indices (r=0.5612, P<0.05). CONCLUSION: Liver mass in patients with liver cirrhosis is related to hepatic hemodynamics, indices for liver fibrosis and liver pathology.