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| 膀胱癌组织端粒酶活性研究 | |
| 引用本文： | 徐子强,范玉铃,韩淑玲. 膀胱癌组织端粒酶活性研究[J]. 天津医科大学学报, 2002, 8(3): 359-360 |
| 作者姓名： | 徐子强 范玉铃 韩淑玲 |
| 作者单位： | 1. 天津市第一中心医院,泌尿外科,天津,300192 2. 天津市第一中心医院,检验科,天津,300192 |
| 摘 要： | 目的：探索端粒酶活性与膀胱癌发生发展的关系。方法：采用TRAP-PCR-ELISA方法检测39例膀胱癌组织、25例癌旁组织及10例正常膀胱组织的端粒酶活性。结果：膀胱癌组织中端粒酶表达阳性率为89.7%(35/39)。癌旁组织中端粒酶表达阳性率为20%（5/25），正常组织中无端粒酶活性表达。结论：端粒酶活性与膀胱癌发生发展密切相关。有可能成为预测膀胱癌复发的肿瘤标记物。 |
| 关 键 词： | 膀胱癌 端粒酶活性 肿瘤复发 TRAP PCR ELISA |
| 文章编号： | 1006-8147(2002)03-0359-02 |
| 修稿时间： | 2002-02-25 |
Telomerase activity in human bladder carcinoma |
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| XU Zi-qiang ,FAN Yu-ling ,HAN Shu-ling. Telomerase activity in human bladder carcinoma[J]. Journal of Tianjin Medical University, 2002, 8(3): 359-360 | |
| Authors: | XU Zi-qiang FAN Yu-ling HAN Shu-ling |
| Affiliation: | XU Zi-qiang 1,FAN Yu-ling 1,HAN Shu-ling 2 |
| Abstract: | Objective:To study the possible relationship between telomerase activity and progression of human bladder carcinoma.Methods:Telomerase activity was examined by TRAP_PCR_ELISA in tissue sample which were taken from 39 bladder carcinoma,25 adjacent noncancerous bladders and 10 normal bladders.Results:The positive rate of telomerase acitivity was 89.7%(35/39),20%(5/25)and 0%(0/10)in bladder carcinoma,in adjavent noncancerous bladder and in normal bladder respectively.Conclusion:Telomerase activity might contribute to progression of bladder carcinoma and could perhaps be a useful tumor marker for the detection of early recurrent bladder carcinoma. |
| Keywords: | Bladder tumor Carcinoma Telomerase |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |