恶性肿瘤的死亡风险与协同刺激分子B7-H4表达的关系

目的 探讨恶性肿瘤死亡风险与协同刺激分子B7-H4表达的关系.方法 制定原始文献的检索方案、纳入标准与排除标准,在PubMed与中国学术期刊网全文数据库(CNKI)、万方数据库、中文期刊上联合检索1999至2009年发表的论文.应用Stata 10.1软件对相关文献进行齐性检验,以(HR)值和95%CI为效应指标,根据一致性检验的结果,选择效应模型对HR值进行合并,并进行偏倚评估.结果 共检索到相关文献35篇,6篇进入Meta统计分析,异质性检验(x2=9.61,df=5,P＞0.05),选择固定效应模型进行估计.多因素分析合并HR值为1. 42(95%CI为1.16～1.72).结论 协同刺激分子B7-H4高表达与恶性肿瘤患者死亡风险密切相关,B7-H4可能是影响恶性肿瘤患者长期生存的一个负性调节分子.

Association between expression of B7-H4 and death risk of malignant tumors

Objective To evaluate the association between expression of B7-H4 and death risk of malignant tumors. Methods We searched the published papers in the PubMed, CNKI,Wanfang Database and Chinese Academic Journal, from 1999 to 2009 according to the developing searching program, inclusion criteria and exclusion criteria of the original literature. Taking into account the results of heterogeneity test using stata10. 1 software, fixed effect model or random effect model was chosen to calculate the combined hazard Ratio (HR) and its corresponding 95% confidence interval (CI), meanwhile publication bias was also evaluated. Results There were 35 papers searched, and only 6 entered Meta-analysis procedure. According to heterogeneity test results (x2 = 9. 61, df = 5 ,P ＞0.05 ), fixed effect model was used.The combined-HR was 1.42, and 95% CI was (1.16-1.72). Conclusion Higher B7-H4 expression is closely related to the death risk of the patients with cancer, and B7-H4 may be a negative regulatory molecules affecting the survival time of malignant tumor patients.