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Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response
Authors:Korneliusz Golebski  Janice A. Layhadi  Umit Sahiner  Esther H. Steveling-Klein  Madison M. Lenormand  Rachael C.Y. Li  Suzanne M. Bal  Balthasar A. Heesters  Gemma Vilà-Nadal  Oliver Hunewald  Guillem Montamat  Feng Q. He  Markus Ollert  Oleksandra Fedina  Mongkol Lao-Araya  Susanne J.H. Vijverberg  Anke-Hilse Maitland-van der Zee  Cornelis M. van Drunen  Mohamed H. Shamji
Affiliation:1. Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands;2. Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands;3. Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Department of National Heart and Lung Institute, Imperial College London, London, UK;4. NIHR Biomedical Research Centre, Asthma UK Centre in Allergic Mechanisms of Asthma, London, Imperial College London, London, UK;5. Department of Dermatology, Allergy Unit, University Hospital Basel, Basel, Switzerland;6. Department of Infection and Immunity, Luxembourg Institute of Health (LIH), 29, rue Henri Koch, 4354 Esch-sur-Alzette, Luxembourg;7. Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark;8. Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany;9. Department of Dermatology and Allergy Center, Odense Research Centre for Anaphylaxis (ORCA), University of Southern Denmark, Odense, Denmark;10. Department of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Abstract:
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  • Keywords:innate lymphoid cells  group 2 innate lymphoid cells  IL-10  allergy  immunotherapy  retinoic acid  allergen specific immunotherapy  KLRG1  plasticity
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