The Impact of Bone Mineral Density on Bone Metabolism and the Fracture Healing Process in Elderly Chinese Patients With Osteoporotic Vertebral Compression Fractures |
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| Authors: | Haoran Qi Jun Qi Junying Gao Jianmin Sun Guodong Wang |
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| Affiliation: | 1. Department of Spine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China;2. Laboratory Department, Jinan Infectious Diseases Hospital, Jinan, China;3. Ocean University of China, Qingdao, China;4. Department of Spine, Provincial Hospital Affiliated to Shandong First medical University, Jinan, China;5. School of Medicine, Shandong University, Jinan, China;1. Division of Radiology, Department of Medical Technology, Kyushu University Hospital, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan;2. Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan;3. Philips Japan, 2-13-37, Konan, Minato-ku, Tokyo 108-8507, Japan;1. Department of Internal Medicine, Military Hospital, Tunis, Tunisia;2. Department of Rheumatology, Rabta Hospital,Tunis, Tunisia;3. Department of Clinical Biochemistry, Pateur Institute,Tunis, Tunisia;4. Department of Immunology, Rabta Hospital, Tunis, Tunisia;5. Department of Nephrology, Rabta Hospital, Tunis, Tunisia;6. University of Tunis El Manar – Tunisia;1. Department of Endocrinology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, (MAHE), Manipal, India;2. Department of Endocrinology, Diabetes & Metabolism, Christian Medical College, Vellore, India;1. Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE, USA;2. Department of Biomechanics, Biomechanics Research Building, University of Nebraska Omaha, Omaha, NE, USA;1. Pediatric Endocrinology and Diabetes Unit, The Edmond and Lily Safra Children''s Hospital, Sheba Medical Center, Tel-Hashomer, Israel;2. The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;3. Division of Endocrinology, Diabetes and Metabolism, Sheba Medical Center, Tel-Hashomer, Israel;4. Division of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children''s Hospital, Sheba Medical Center, Tel Hashomer, Israel |
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| Abstract: | ![]()
Background: The aim of this study was to investigate the effect of bone mineral density (BMD) on bone histomorphological parameters and bone turnover markers (BTMs) following osteoporotic vertebral compression fracture (OVCF) and to determine the correlation between BMD and the percentage of middle height compression during the healing process. Methods: A total of 206 patients with OVCFs were included in this study. Bone biopsy specimens were acquired during surgery. Blood samples were obtained to determine the serum concentrations of BTMs. The patients were divided into 2 groups according to BMD.Results: The concentrations of N-terminal propeptide of type I collagen (PINP) in the T-score ≤ ?2.5 group (50.92 ± 12.78 ng/ml) were significantly lower than those in the T-score > ?2.5 group (68.75 ± 28.66 ng/ml, p = 0.025) 3–6 mo after fracture. Moreover, the volume of necrotic bone in the T-score ≤ ?2.5 group (15.15 ± 5.44%) was higher than that (1.67 ± 0.79%, p < 0.001) in the T-score > ?2.5 group during the same period. BMD was statistically correlated with cancellous bone content (RS = 0.761, p <0.001), PMHC (RS = 0.85, p < 0.001), fibrous tissue volume (RS = ?0.376, p < 0.001), and necrotic bone content (RS = ?0.487, p < 0.001).Conclusions: The healing process of OVCFs in the setting of low bone mass frequently occurs in the presence of decreased bone formation abilities, severe vertebral body height loss and a large amount of necrotic bone. |
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