|
|||||
|
|
Testing association of rare genetic variants with resistance to three common antiseizure medications |
|
| Authors: | Stefan Wolking Claudia Moreau Anne T. Nies Elke Schaeffeler Mark McCormack Pauls Auce Andreja Avbersek Felicitas Becker Martin Krenn Rikke S. Møller Marina Nikanorova Yvonne G. Weber Sarah Weckhuysen Gianpiero L. Cavalleri Norman Delanty Chantal Depondt Michael R. Johnson Bobby P.C. Koeleman Wolfram S. Kunz Anthony G. Marson Josemir W. Sander Graeme J. Sills Pasquale Striano Federico Zara Fritz Zimprich Matthias Schwab Roland Krause Sanjay M. Sisodiya Patrick Cossette Simon L. Girard Holger Lerche EpiPGX Consortium |
| Affiliation: | 1. Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany;2. Department of Applied Sciences, University of Quebec in Chicoutimi, Saguenay, Canada;3. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;4. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany University of Tübingen, Tübingen, Germany;5. Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland;6. Walton Centre NHS Foundation Trust, Liverpool, UK;7. Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK Chalfont Centre for Epilepsy, London, UK;8. Department of Neurology, Medical University of Vienna, Vienna, Austria;9. Danish Epilepsy Centre - Filadelfia, Dianalund, Denmark;10. Department of Regional Health Research, University of Southern Denmark, Odense, Denmark;11. Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany Department of Epileptology and Neurology, University of Aachen, Aachen, Germany;12. Neurogenetics Group, VIB-UAntwerp, Center for Molecular Neurology, Antwerp, Belgium Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium Department of Neurology, Antwerp University Hospital, Antwerp, Belgium;13. Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium;14. Division of Brain Sciences, Imperial College Faculty of Medicine, London, UK;15. Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands;16. Institute of Experimental Epileptology and Cognition Research and Department of Epileptology, University of Bonn, Bonn, Germany;17. Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK;18. Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK Chalfont Centre for Epilepsy, London, UK Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands;19. IRCCS "G. Gaslini" Institute, Genova, Italy;20. Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy;21. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany University of Tübingen, Tübingen, Germany Department of Clinical Pharmacology, Pharmacy and Biochemistry, University Tübingen, Tübingen, Germany;22. Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg;23. Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK;24. Department of Neurosciences, Research Center of the University of Montreal Hospital Center (CRCHUM), University of Montreal, Montreal, Canada |
| Abstract: | |
| Keywords: | burden analysis lamotrigine levetiracetam pharmacogenomics rare variants valproic acid |