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| 胸腺因子D对老年大鼠肝微粒体,线粒体钙离子转运的影响 | |
| 引用本文： | 李林 周金黄. 胸腺因子D对老年大鼠肝微粒体,线粒体钙离子转运的影响[J]. 中国药理学与毒理学杂志, 1992, 6(3): 224-227 |
| 作者姓名： | 李林 周金黄 |
| 作者单位： | 北京老年病医疗研究中心，军事医学科学院毒物药物研究所，军事医学科学院毒物药物研究所，空军福州医院 北京 100053，北京 100850，北京 100850，福州 350002 |
| 摘 要： | 应用~(45)Ca研究了胸腺因子D(TFD)对老年大鼠肝脏亚细胞结构Ca~(2+)转运的影响,结果表明,与成年对照鼠(7月龄)相比,雄性老年大鼠(24月龄)肝微粒体,线枉体膜Ca(2+)主动摄取能力降低,肝微粒体Ca(2+)被动释放增多,给老年大鼠TFD 2 mg·kg~(-1)sc隔日一次共3月,可使其肝微枉体Ca(2+)主动摄取能力提高,Ca(2+)被动释放减少,有利于维持细胞内钙穗态,同时TFD还可逆转老年大鼠肝微粒体,线粒体膜流动性的降低及过氧化脂质的增高。 |
| 关 键 词： | 衰老 胸腺 肝脏 钙 膜流动性 脂质过氧化 |
Effects of thymic factor D on Ca~(2+) transfer of liver microsome and mitochondria in aged rats |
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| LI Lin,ZHOU Jin-Huang,XING Shan-Tian,CHEN Zi-RongInstitute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing Beijing Geriatric Clinical and Research Center,Beijing Fuzhou Hospital,Fuzhou. Effects of thymic factor D on Ca~(2+) transfer of liver microsome and mitochondria in aged rats[J]. Chinese Journal of Pharmacology and Toxicology, 1992, 6(3): 224-227 | |
| Authors: | LI Lin ZHOU Jin-Huang XING Shan-Tian CHEN Zi-RongInstitute of Pharmacology Toxicology Academy of Military Medical Sciences Beijing Beijing Geriatric Clinical Research Center Beijing Fuzhou Hospital Fuzhou |
| Affiliation: | LI Lin,ZHOU Jin-Huang,XING Shan-Tian,CHEN Zi-RongInstitute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850 Beijing Geriatric Clinical and Research Center,Beijing 100053Fuzhou Hospital,Fuzhou 350002 |
| Abstract: | The experiments by using 45Ca were performed to investigate Ca2+ transfer of the liver subcellular fraction in the male aged Wistar rats (24-month-old) and the effects of thymic factor D (TFD), extracted from the pig thymus, on these parameters. It was found in the aged rats that Ca2+ uptake of the liver microsome and mitochondria showed a significant decrease, with a simultaneous increase inthe passive Ca2+ release from the liver microsome. TFD, given to the aged rats, at a dose of 2 mg·kg-1 sc every other day for 3 month increased Ca2+ uptake of the liver microsome and decreased the passive Ca2+ release from the liver microsome, showing a beneficial effect on maintaining intracellular calcium homeostasis. In addition, TFD reversed an increase of lipid peroxides and a decrease of membrane fluidity in the liver microsome and mitochondria of the aged rats |
| Keywords: | aging thymus liver calcium membrane fluidity lipid peroxidation |
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