幽门螺杆菌感染与胃癌关系的Meta 分析

目的　确定幽门螺杆菌感染与胃癌的关系 ,为探讨胃癌的病因和防治措施提供依据。方法　用计算机辅以手工检索原始文献 ,用Meta -分析方法中的随机效应模型 (D -L法 )对检索到的国内 2 3篇病例对照研究进行综合定量分析 ,求得综合比值比 (OR) ,并对该综合分析结果及可能出现的偏倚进行讨论。结果　幽门螺杆菌感染与胃癌的发生有明显的联系 (OR =2 .5 9,95 %CI:1.82～ 3 .6 8) ;其中与胃非贲门部癌、腺癌的联系具有统计学意义 ,其合并OR(95 %CI)依次为 3.35 (1.30～ 8.5 9)、3 .94(2 .41～ 6 .42 ) ;与胃贲门部癌及非腺癌的联系无统计学意义 (OR =1.38,95 %CI :0 .91～ 2 .0 8;OR =1.5 5 ,95 %CI :0 .99～ 2 .44 )。结论　幽门螺杆菌感染与胃癌的发生尤其是非贲门部癌、腺癌确实存在联系

Meta - analysis of helicobacter pylori infection and gastric carcinoma

Objective To determine the association of helicobacter pylori(Hp) infection with gastric carcinoma and to provide evidence for the etiology and preventive measures of gastric carcinoma. Methods Used Meta-analysis (D-L ways), the data of 23 indexed case -control study reports were studied, and calculated the combined odds ratio(OR). Results Hp infection had significant association with gastric carcinoma(OR=2.59,95% CI:1.82～3.68), and was especially statistically difference between the Hp infection and non-cardiac carcinoma and gastric adenocarcinoma, the combined OR(95% CI)was 3.35(1.30～8.59) and 3.94(2.41～6.42);but Hp infection had no statistical significance with cardiac carcinoma and no-adenocarcinoma(OR=1.38,95%CI:0.91～2.08) and (OR=1.55,95%CI:0.99～2.44) Conclusion A significant association exists between Hp infection and gastric carcinoma, especially in the case of non-cardiac gastric carcinoma and adenocarcinoma.