| 单核细胞趋化蛋白1及其受体CCR2与冠心病关系的研究进展 |
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| 引用本文： | 苏林丘. 单核细胞趋化蛋白1及其受体CCR2与冠心病关系的研究进展[J]. 医学综述, 2011, 17(16): 2411-2414 |
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| 作者姓名： | 苏林丘 |
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| 作者单位： | 福建医科大学省立临床医学院,福州,350001 |
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| 摘 要： | 冠状动脉粥样硬化性心脏病是一种慢性炎症性疾病,炎性反应在动脉粥样硬化(AS)发生、发展及其并发症的产生过程中起着重要作用,而趋化因子及受体在炎性反应中起关键作用。其中单核细胞趋化蛋白1(MCP-1)被认为是AS发生早期的关键因素,它与其特异性受体CC类趋化因子受体2(CCR2)结合后,趋化并激活单核/巨噬细胞,促进炎性反应的发生,从而产生生物学效应。现就MCP-1及CCR2在冠心病炎性反应过程中的作用,以及治疗冠心病的可行方案予以综述。
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| 关 键 词： | 单核细胞趋化蛋白1 CC类趋化因子受体2 冠状动脉粥样硬化性心脏病 |
Research Progress of the Correlation between Monocyte Chemoattractant Protein-1 and the Receptor CCR2 and Coronary Heart Disease |
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| SU Lin-qiu. Research Progress of the Correlation between Monocyte Chemoattractant Protein-1 and the Receptor CCR2 and Coronary Heart Disease[J]. Medical Recapitulate, 2011, 17(16): 2411-2414 |
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| Authors: | SU Lin-qiu |
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| Affiliation: | SU Lin-qiu1,CHEN De-wei2.(1.Fujian Provincial Clinical Medical College,Fujian Medical University,Fuzhou 350001,China,2.Department of Cardiovascular Medicine,Cardiovascular Research Institute,Fujian Provincial Hospital,China) |
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| Abstract: | Coronary atherosclerotic heart disease(CAHD)is a chronic inflammatory disease,inflammation has an important effect in the atherosclerosis(AS)occurrence and development and the process of its complications,chemotactic factors and receptors play a key role in the inflammation.Among them,monocyte chemoattractant protein-1(MCP-1)is considered as a critical factor in the early formation of atherosclerotic plaques,which can make monocyte/macrophages chemotactic and active,promote inflammation,result in the occurr... |
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| Keywords: | Monocyte chemoattractant protein-1 CC chemokine receptor 2 Coronary atherosclerotic heart disease |
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