应激致血压升高大鼠压力反射敏感性的频谱分析方法测定

通过心率变异性和高血压变异性的频谱分析，计算机血压为输入 ，心搏间隔为输出的传递函数，以传递函数的模量作为压发作敏性的指标。

The Measurement of Baroreflex Sensitivity in Stress Induced Hypertensive Rats by Spectral Analysis

Simultaneous spectral analysis of short term systolic blood pressure variability (SBPV) and heart rate variability (HRV) was applied to determine the change of baroreflex sensitivity (BRS) in Sprague Dawley (SD) rats.The modulus of the transfer function between fluctuations in systolic pressure and beat to beat interval would be an appropriate quantification of BRS.The animal experiment was performed on two groups of rats:normotensive rats and stress induced hypertensive rats (SIHR).V 1 receptor antagonist d(CH 2) 5Tye(Me) AVP of arginine vasopressin (AVP) was microinjected into intracerebroventricle.The results showed that,in base line condition before administration,although the BRS in very low frequency band(0 0.035 Cycle/Beat,VLF),low frequency band (0.035 0.12 Cycle/Beat,LF),high frequency band (0.12 0.32 Cycle/Beat,HF) and total BRS(the sum of the three bands) were all decreased,the BRS in VLF( P <0.05)and LF( P<0.01) decreased significantly by statistics;and that,to the SIHR,the BRS in VLF was significantly lower after AVP V 1 administration than in base line condition,while to normotensive rats,the BRS did not change.It indicates that the facilitating effect of AVP on the beroreflex in SIHR is mainly due to V 1 receptor in central nerve system.In summary,the transfer function between SBPV and beat to beat interval fluctuation could be an index of BRS.This method can be developed for future clinical application.