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| 肌成纤维细胞在病理性瘢痕形成中的机制 | |
| 引用本文： | 刘勇,岑瑛,唐颖,许学文. 肌成纤维细胞在病理性瘢痕形成中的机制[J]. 中国修复重建外科杂志, 2005, 19(1): 39-41 |
| 作者姓名： | 刘勇 岑瑛 唐颖 许学文 |
| 作者单位： | 1. 四川大学华西医院整形烧伤科,成都,610041 2. 四川大学华西医院整形病理科,成都,610041 |
| 摘 要： | 目的 探讨肌成纤维细胞在病理性瘢痕形成机制中的作用。方法 对1998年～2000年门诊或住院的13例增生性瘢痕，14例瘢痕疙瘩及7例成熟瘢痕患者的相应组织，应用光镜、电镜及免疫组织化学染色，进行观察、检测。结果 增生性瘢痕的超微结构中均可见典型的肌成纤维细胞；免疫组织化学染色可见有不同程度表达的肌成纤维细胞。瘢痕疙瘩及成熟瘢痕的超微结构和免疫组织化学结果均未见肌成纤维细胞。结论 肌成纤维细胞的生物学行为可能与增生性瘢痕的形成及瘢痕畸形有关，并可用于增生性瘢痕与瘢痕疙瘩的鉴别。 |
| 关 键 词： | 肌成纤维细胞 增生性瘢痕 病理性瘢痕 瘢痕疙瘩 免疫组织化学染色 超微结构 住院 用光 |
| 修稿时间： | 2003-10-20 |
THE ROLE OF MYOFIBROBLAST IN THE DEVELOPMENT OF PATHOLOGICAL SCAR |
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| LIU Yong,CEN Ying,TANG Ying,et al.. THE ROLE OF MYOFIBROBLAST IN THE DEVELOPMENT OF PATHOLOGICAL SCAR[J]. Chinese journal of reparative and reconstructive surgery, 2005, 19(1): 39-41 | |
| Authors: | LIU Yong CEN Ying TANG Ying et al. |
| Affiliation: | Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu Sichuan 610041, P R China. |
| Abstract: | OBJECTIVE: To study the effect of myofibroblast on the development of pathological scar. METHODS: From 1998 to 2000, 14 cases of keloid(k), 13 cases of hypertrophic scar(HS), and 7 cases of scar were studied through immunohistochemistry and electronical microscope. RESULTS: Myofibroblasts were often observed in the hypertrophic HS by electronical microscope, but no myofibroblast was observed in the K and NS. alpha-SM-actin was expressed in fibroblast of HS, but was not expressed in K and NS. CONCLUSION: Myofibroblast may play a role in the development of hypertrophic scar. The difference between the absence of myofibroblast in keloid and the invasion of keloid deserves further study. |
| Keywords: | Hypertrophic scar Keloid Myofibroblast |
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