清解凉利法治疗小儿急性肾炎的临床研究 |
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引用本文: | 张维真,李敬顺.清解凉利法治疗小儿急性肾炎的临床研究[J].中国中西医结合杂志,1999,0(3):141-143. |
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作者姓名: | 张维真 李敬顺 |
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作者单位: | 南京市儿童医院 |
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摘 要: | 目的:探讨一氧化氮(NO)与小儿急性肾炎发病关系及中西医结合治疗对其影响。方法:将44例急性肾炎患儿分为两组,甲组采用凉利法加西药,乙组采用清热凉利法加西药。
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关 键 词: | 清解凉利法 肾炎 一氧化氮 儿童 中医药疗法 |
Clinical Study of Treating Infantile Acute Nephritis with Antipyretic and Detoxication, Cooling Blood and Diuretic Principle |
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Authors: | Zhang Weizhen |
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Abstract: | OBJECTIVE: To find out the relationship between nitric oxide and onset of infantile acute nephritis, and the effect of traditional Chinese medicine (TCM) and Western medicine (WM) combination therapy. METHODS: Dividing 44 infantile acute nephritis patients into two groups. Group 1 was treated with cooling blood and diuretic principle, together with WM, Group 2 was treated with antipyretic and detoxication, cooling blood and diuretic principle, together with WM. The content of nitrite/nitrate iron (Fe NO2/NO3) in blood before and after treatment were determined through Griess nitrate reduction method, then compared with that of 28 healthy children. RESULTS: The content of Fe NO2/NO3 being in acute nephritis period was obvious higher than that of control group and reconvalecent period, P < 0.01. The macroscopic hematuria was higher than that of microscopic hematuria, P < 0.01. Urinary alexin third element (C3) and alpha 2-macroglobulin (alpha 2-M) positive patients Fe NO2/NO3 was higher than that of negative ones, P < 0.01. Those complicated with infection Fe NO2/NO3 was higher than that without infection P < 0.01. Short term cure rate of group 2 was higher than that of group 1, P < 0.05. Nitric oxide may participate the onset and pathogenesis of infantile acute nephritis. CONCLUSION: TCM-WM combination therapy, especially antipyretic and detoxication, cooling blood and diuretic principle, could restrain nitric oxide from damaging tissue and remitting disease. |
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Keywords: | antipyretic and detoxication cooling blood and diuretil principle infantile nephritis nitric oxide |
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