急性心肌梗死患者血清肌红蛋白、N末端B型利钠肽原与经皮冠状动脉介入术后预后的关系

目的 分析急性心肌梗死(AMI)患者血清肌红蛋白(Myo)、N末端B型利钠肽原(NT-proBNP)水平及临床意义.方法 我院接受急诊经皮冠状动脉介入术(PCI)治疗的AMI患者150例(AMI组),根据AMI术后主要不良心血管事件(MACE)发生与否分为MACE组(n=32)与非MACE组(n=118).选择同期健康...

The relationship between the levels of serum myoglobin and N-terminal pro-B-type natriuretic peptide and the prognosis after PCI in patients with acute myocardial infarction

Objective To analyze the levels of serum myoglobin(Myo)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)in patients with acute myocardial infarction(AMI)and their clinical significance.Methods One hundred and fifty AMI patients who received emergency percutaneous coronary intervention(PCI)treatment in our hospital were classified as an AMI group.According to whether major adverse cardiovascular events(MACE)occurred or not after AMI,the AMI patients were further divided into a MACE group(n=32)and a non-MACE group(n=118).Another 150 healthy volunteers who underwent physical examination in our hospital during the same period were selected as a control group.The differences of Myo and NT-proBNP levels and left ventricular ejection fraction(LVEF)in different groups were compared.The correlation between the levels of Myo and NT-proBNP and the LVEF was analyzed.The risk factors of MACE were also analyzed.Results Thelevels of serum Myo and NT-proBNP in the AMI group were higher and the level of LVEF was lower than those in the control group(P<0.05).Myo and NT-proBNP were negatively correlated with LVEF(P<0.05).The levels of serum Myo and NT-proBNP in the MACE group were higher than those in the non-MACE group(P<0.05).ROC analysis showed that the best cut-off values of serum Myo and NT-proBNP for predicting MACE after PCI in the AMI patients were 243.84μg/L and 3326.01 ng/L,respectively.Logistic regression analysis found that high Killip grade,high HbA1c level,MYO>243.8μg/L,and NT-proBNP>3,326.01 ng/L were independent risk factors for MACE after PCI in AMI patients(P<0.05).Conclusion The levels of Myo and NT-proBNP in patients with AMI can initially reflect the cardiac function status.They also have a predictive value forthe occurrence of MACE after PCI.