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Bioassay guided purification of the antimicrobial fraction of a Brazilian propolis from Bahia state |
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| Authors: | Myrella Lessio Castro Walquíria Ribeiro Vilela Rogéria Cristina Zauli Masaharu Ikegaki Vera Lúcia Garcia Rehder Mary Ann Foglio Severino Matias de Alencar Pedro Luiz Rosalen |
| Affiliation: | 1. Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), Avenida Limeira, 901, 13414-903, Piracicaba, SP, Brazil 2. Department of Agri-Food Industry, Food and Nutrition, Escola Superior de Agricultura "Luiz de Queiroz", University of S?o Paulo (USP), Avenida Pádua Dias, 11, 13418900, Piracicaba, SP, Brazil 3. Department of Pharmacy, Federal University of Alfenas, Alfenas, MG, Brazil 4. Avenida Gabriel Monteiro da Silva, 700, 37130-000, Alfenas, MG, Brazil 5. Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas (UNICAMP), C.P. 6171, 13081-970, Campinas, SP, Brazil |
| Abstract: | BackgroundBrazilian propolis type 6 (Atlantic forest, Bahia) is distinct from the other types of propolis especially due to absence of flavonoids and presence of other non-polar, long chain compounds, but presenting good in vitro and in vivo antimicrobial activity. Several authors have suggested that fatty acids found in this propolis might be responsible for its antimicrobial activity; however, so far no evidence concerning this finding has been reported in the literature. The goals of this study were to evaluate the antibacterial activity of the main pure fatty acids in the ethanolic extract and fractions and elucidate the chemical nature of the bioactive compounds isolated from Brazilian propolis type 6. |
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