The dopamine transporter: role in neurotoxicity and human disease |
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| Authors: | Bannon Michael J |
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| Affiliation: | Department of Psychiatry and Behavioral Neuroscience, Pharmacology, and Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA. mbannon@med.wayne.edu |
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| Abstract: | The dopamine transporter (DAT) is a plasma membrane transport protein expressed exclusively within a small subset of CNS neurons. It plays a crucial role in controlling dopamine-mediated neurotransmission and a number of associated behaviors. This review focuses on recent data elucidating the role of the dopamine transporter in neurotoxicity and a number of CNS disorders, including Parkinson disease, drug abuse, and attention deficit hyperactivity disorder (ADHD). |
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| Keywords: | Dopamine transporter Neurotoxicity Human disease |
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