| 正交试验优选复方银杏叶片的处方研究 |
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| 引用本文： | 危华玲,潘洪平,卢文胜. 正交试验优选复方银杏叶片的处方研究[J]. 中国药房, 2006, 17(10): 736-737 |
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| 作者姓名： | 危华玲 潘洪平 卢文胜 |
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| 作者单位： | 1. 广西壮族自治区人民医院,南宁市,530021
2. 广西医科大学附属第三医院,南宁市,530031 |
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| 摘 要： | 目的:筛选复方银杏叶片的最佳处方。方法:采用正交设计试验,以多指标(片重差异、崩解度)综合评分法,筛选最佳处方(低取代羟丙基纤维素用量、原料药与填充剂的用量比例、微晶纤维素用量)。结果:最佳处方系低取代羟丙基纤维素用量为5%,原料药与填充剂的用量比例为1∶1,微晶纤维素用量为10%。结论:该片剂处方合理,且片剂成型质量好。
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| 关 键 词： | 正交试验 复方银杏叶片 处方 |
| 文章编号： | 1001-0408（2006）10-0736-02 |
| 收稿时间： | 2006-02-07 |
| 修稿时间： | 2006-04-03 |
Optimization of the Formula of Compound Ginkgo Leaves Tablets by Orthogonal Experiment |
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| WEI Hualing,PAN Hongping,LU Wensheng. Optimization of the Formula of Compound Ginkgo Leaves Tablets by Orthogonal Experiment[J]. China Pharmacy, 2006, 17(10): 736-737 |
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| Authors: | WEI Hualing PAN Hongping LU Wensheng |
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| Abstract: | OBJECTIVE:To optimize the formula of the compound ginkgo leaves tablets.METHODS:The formula(dosage of low-substituted hydroxypropyl cellulose;the ratio between crude drug and loading agent and the dosage of micro-crystalline cellulose)was optimized using orthogonal design and multi-index(tablet weight variation and disintegration de-gree)comprehensive score method.RESULTS:The optimized formula was the following:the dosage of low-substituted hy-droxypropyl cellulose was5%;the ratio between crude drug and loading agent was1∶1and the dosage of microcrystalline cellulose was10%.CONCLUSION:The tablets are reasonable in formula and the forming quality of which is also good. |
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| Keywords: | Orthogonal design Compound ginkgo leaves tablets Formula |
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