Fetal RhD genotyping: A more efficient use of anti-D immunoglobulin |
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Authors: | G Daniels K Finning P Martin J Summers |
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Institution: | aBristol Institute for Transfusion Sciences and International Blood Group Reference Laboratory, NHSBT, Southmead Road, Bristol BS10 5SB, United Kingdom |
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Abstract: | The most important application of blood group genotyping by molecular genetics is the prediction of fetal RhD phenotype in pregnant women with anti-D, in order to assess the risk of haemolytic disease of the fetus and newborn. This diagnostic test performed on cell-free fetal DNA in the maternal plasma, is now a routine procedure in some countries. High-throughput modifications of this form of fetal D-typing would be valuable for testing fetuses of all D-negative pregnant women to avoid unnecessary antenatal treatment with anti-D immunoglobulin in the 40% of D-negative pregnant women with a D-negative fetus. The results of trials in Bristol and Amsterdam suggest that such routine testing is feasible and accurate. |
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Keywords: | Rhesus RhD Genotyping antenatal diagnosis Fetal DNA Maternal plasmaMots clé s: Rhé sus RhD Gé notypage Diagnostic pré natal ADN fœ tal Plasma maternel |
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