| 补阳还五汤加减辅助治疗气阴两虚兼血瘀型非增殖期糖尿病视网膜病变 |
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| 引用本文： | 李英,高娜,黄群,田霞,赵敏,曾学利.补阳还五汤加减辅助治疗气阴两虚兼血瘀型非增殖期糖尿病视网膜病变[J].国际眼科杂志,2022,22(1):99-103. |
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| 作者姓名： | 李英 高娜 黄群 田霞 赵敏 曾学利 |
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| 作者单位： | 610072 中国四川省成都市,成都中医药大学附属医院眼科 |
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| 基金项目： | 四川省卫生和计划生育委员会科研课题(No.17PJ534) |
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| 摘 要： | 目的:观察补阳还五汤加减辅助治疗气阴两虚兼血瘀型非增殖期糖尿病视网膜病变疗效及对患者中医证候和视功能水平的影响.方法:选取2017-01/2019-12期间我院气阴两虚兼血瘀型非增殖期糖尿病视网膜病变患者110例,进行回顾性分析,根据治疗方式分为观察组55例110眼、对照组55例110眼,对照组参考相关指南根据患者病情程度予以常规治疗,观察组患者在此基础上联合补阳还五汤加减辅助治疗.比较两组患者治疗3mo临床疗效,治疗前、治疗3mo中医证候积分,临床指标(黄斑水肿情况评分、黄斑视网膜体积、黄斑中心凹视网膜厚度),视功能(最佳矫正视力、视野平均敏感度),以及血清生化指标血管内皮生长因子(VEGF)、低氧诱导因子-1(HIF-1)].结果:治疗3mo后,观察组治疗总有效率显著高于对照组(P<0.05);治疗3mo后,两组患者中医证候积分均较治疗前降低,且观察组低于对照组(P<0.05);治疗3mo后,两组患者黄斑水肿情况评分、黄斑视网膜体积、黄斑中心凹视网膜厚度均较治疗前减小,且观察组小于对照组(P<0.05);治疗3mo后,两组患者最佳矫正视力、视野平均敏感度均较治疗前改善,且观察组优于对照组(P<0.05);治疗3mo后,两组患者血清VEGF、HIF-1水平均较治疗前降低,且观察组低于对照组(P<0.05).结论:补阳还五汤加减辅助治疗气阴两虚兼血瘀型非增殖期糖尿病视网膜病变疗效确切,可能通过降低VEGF、HIF-1表达改善症状,促进视功能恢复.
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| 关 键 词： | 补阳还五汤 气阴两虚 血瘀 非增殖期糖尿病视网膜病变 视功能 |
| 收稿时间： | 2021/5/15 0:00:00 |
| 修稿时间： | 2021/12/1 0:00:00 |
Efficacy of addition and subtraction of Buyang Huanwu decoction in the adjuvant treatment of non-proliferative diabetic retinopathy of Qi-Yin deficiency and blood stasis |
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| Ying Li,Na Gao,Qun Huang,Xia Tian,Min Zhao and Xue-Li Zeng.Efficacy of addition and subtraction of Buyang Huanwu decoction in the adjuvant treatment of non-proliferative diabetic retinopathy of Qi-Yin deficiency and blood stasis[J].International Journal of Ophthalmology,2022,22(1):99-103. |
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| Authors: | Ying Li Na Gao Qun Huang Xia Tian Min Zhao and Xue-Li Zeng |
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| Institution: | Department of Ophthalmology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China,Department of Ophthalmology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China,Department of Ophthalmology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China,Department of Ophthalmology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China,Department of Ophthalmology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China and Department of Ophthalmology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China |
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| Abstract: | |
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| Keywords: | Buyang Huanwu decoction Qi-Yin deficiency blood stasis non-proliferative diabetic retinopathy visual function |
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