蓝盆花属植物化学成分及药理活性研究进展

川续断科蓝盆花属植物大多数在国内外广泛作为民间传统用药,潜在药用价值较大。通过Sci Finder,Pub Med,中国知网,万方等国内外多个数据库,收集到有关蓝盆花属植物化学成分和药理作用的文献,经全面分析后,分类归纳成综述。至今,蓝盆花属植物中所含化学成分类型较多,主要有黄酮类、三萜类、环烯醚萜、香豆素类、酚类、有机酸和挥发油等结构类型。药理作用有解热抗炎、抗氧化、抗血小板聚集、镇静、增强免疫等功能,尤其是在抗氧化和抑菌等方面效果显著。主要有效成分为黄酮类和三萜类。基于近年来国内外对蓝盆花属植物的研究,综述其化学成分结构类型和药理活性研究进展,为全面了解和综合利用蓝盆花属植物、开展发现其新的药用活性成分研究并对其资源保护提供参考。

Chemical Constituents in Scabiosa Plants and Their Pharmacological Activities

Dipsacaceae Scabiosa plants are widely applied in traditional folk herbal medicines at home and abroad, with a great potential medical value. The recent literatures on chemical constituents in Scabiosa and pharmacological effects were collected from SciFinder, PubMed, CNKI, Wanfang date and multiple domestic and foreign batabases. The literatures were analyzed and summarized in to reviews. So far, various chemical constituents, such as flavonoids, triterpennoids, iridoids, coumarins, organic acids, phenolic constituents and volatile oils, were isolated from Scabiosa plants. Their pharmacological effects included antipyresis and anti-inflammation, anti-oxidation, anti-platelet aggregation, sedation and immuno-enhancement, particularly in anti-oxidation and anti-bacteria. Flavonoids and terpenoids were its main effective components. Based on the domestic and foreign studies on Scabiosa plants, the advance in studies on structures and pharmacological effects of the chemical constituents were summarized to provide a reference for the comprehensive study and utilization of Scabiosa plants, the discovery of new active pharmaceutical ingredients and the protection of its resources.