胃胀舒合剂对功能性消化不良大鼠胃排空及血浆胃肠激素水平的影响

目的]观察胃胀舒合剂对功能性消化不良（FD）大鼠胃排空和胃肠激素的影响，探讨其可能的作用机制。方法]采用不规则进食加稀盐酸喂养以及劳倦过度的复合因素制作大鼠FD模型。随机分成胃胀舒合剂高、低剂量（高、低剂量）组、多潘立酮组、正常对照（正常）组、模型对照（模型）组共5组，连续给药14d后，放免法检测血浆胃动素（MOT）和生长抑素（SS）水平，以酚红法观察胃排空。结果]与正常组相比，模型组胃排空和血浆MOT水平显著降低，SS显著升高（均P〈0．05），与模型组相比，高、低剂量及多潘立酮组胃排空和血浆MOT显著升高，SS显著降低（均P〈0．05）。结论]胃胀舒合剂具有促进内源性MOT及抑制SS释放和促进胃排空作用，是其治疗FD机制之一。

Effect of Weizhangshu mixture on gastric emptying and gastrointestinal hormone in rats with functional dyspepsia

Objective]To observe the effects and mechanism of WeiZhangShu mixture on the gastric emptying and gastrointestinal hormone in rats.Methods]Functional dyspepsia models in rats were made by irregularly feeding food plus diluted hydrochloric acid and weary excessively divided randomly into 5groups:high and low dosages of WeiZhangShu mixture,domperidone tablets,blank group and model groups.Treatments were offered for 14 days.The content of motilin and somatostatin in plasma were determined by radiommunoassay....