Copper-catalyzed aerobic decarboxylative coupling between cyclic α-amino acids and diverse C–H nucleophiles with low catalyst loading |
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| Authors: | Jing Guo Ying Xie Qiao-Lei Wu Wen-Tian Zeng Albert S C Chan Jiang Weng Gui Lu |
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| Institution: | Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006 China, Fax: +86-20-3994-3048 |
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| Abstract: | An aerobic decarboxylative cross-coupling of α-amino acids with diverse C–H nucleophiles has been realized using Cu2(OH)2CO3 (1 mol%) as the catalyst under air. This protocol enables highly efficient formation of various C(sp3)–C(sp3), C(sp3)–C(sp2) and C(sp3)–C(sp) bonds under simple conditions without the use of any ligand or extra oxidant, providing a practical approach to numerous nitrogen-containing compounds in good to excellent yields. The efficiency and practicability were also demonstrated by the gram-scale experiment and three-step synthesis of a Rad51 inhibitor.An aerobic decarboxylative cross-coupling of α-amino acids was realized using 1 mol% Cu2(OH)2CO3 catalyst under ligand free conditions. |
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