| 穴位透皮贴剂中丹参酮ⅡA的经皮吸收速率研究 |
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| 引用本文： | 戴居云,赵玲,王颖华,方军. 穴位透皮贴剂中丹参酮ⅡA的经皮吸收速率研究[J]. 现代中西医结合杂志, 2004, 13(24): 3245-3246,3248 |
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| 作者姓名： | 戴居云 赵玲 王颖华 方军 |
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| 作者单位： | 1. 上海中医药大学气功所医疗门诊部,上海,200020
2. 上海中医药大学,上海,200032 |
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| 基金项目： | 国家自然科学青年基金资助项目 (3970 0 1 91 ) |
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| 摘 要： | 目的 采用同位素示踪技术探讨不同促渗方法对丹芪益心贴中丹参酮ⅡA的经皮渗透速率的影响。方法 以3 H标记丹参酮ⅡA为指标 ,根据丹参酮ⅡA粪便排泄分数测定贴膏中丹参酮ⅡA的在体小鼠的透皮速率。结果 促渗剂能显著提高贴膏中丹参酮ⅡA经皮渗透速率 ;硝酸甘油预处理加促渗剂渗透速率明显高于单用促渗剂。结论 丹参酮ⅡA氚标记后用于透皮吸收实验研究是可行的 ,促渗剂加小剂量硝酸甘油预处理皮肤能够加强丹参酮ⅡA的透皮吸收率
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| 关 键 词： | 丹参酮ⅡA 同位素示踪技术 透皮吸收 |
| 文章编号： | 1008-8849(2004)24-3245-03 |
Study of TanshinoneⅡA percutaneous absorption rate in acupoint transdermal |
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| DAI Ju-yun,ZHAO Ling,WANG Ying-hua,FANG Jun. Study of TanshinoneⅡA percutaneous absorption rate in acupoint transdermal[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2004, 13(24): 3245-3246,3248 |
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| Authors: | DAI Ju-yun ZHAO Ling WANG Ying-hua FANG Jun |
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| Affiliation: | DAI Ju-yun1,ZHAO Ling2,WANG Ying-hua1,FANG Jun2 |
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| Abstract: | Objective It is to discuss the influence of differen t enhancing osmosi s methods on TanshinoneⅡA percutaneous absorption rate in DANQIYIXINTIE through using radioisotope tracer technique.Methods Using 3H TanshinoneⅡA as the index, TanshinoneⅡA per cutaneous absorpti on rate in strapping of rat in vitro was tested based on TanshinoneⅡA stool exc retion fraction.Result Enhancing osmosis agent could significantly enhance Tanshin oneⅡA percuta neous absorbtion rate in strapping. The absorption rate of nitroglycerin pretrea tment plus enhancing osmosis agent was obviously higher than that of enhancing o smosis agent only.Conclusion It is a suitable method that TanshinoneⅡA marked by 3H is used in pe rcutaneous absorption empirical study. Enhancing osmosis agent plus low does of nitroglycerin pretreatment on skin can strengthen TanshinoneⅡA percutaneous abs orption rate. |
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| Keywords: | TanshinoneⅡA radioisotope tracer technique percutan eous absorption |
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