苦参素与阿昔洛韦治疗慢性乙型肝炎疗效比较

目的探讨苦参素与阿昔洛韦治疗慢性乙型肝炎的临床疗效及不良反应.方法选择慢性乙型肝炎患者83例,随机分成治疗组42例,给予苦参素600 mg.d-1,im,疗程为3个月;对照组41例,给予阿昔洛韦15mg.kg-1.d-1,缓慢ivgtt,1个月后改为阿昔洛韦片100 mg.d-1,分5次po,连用2个月,同时两组均配合使用常规护肝药物.疗效结束时,观察两组患者临床症状体征,肝功能及乙肝病毒血清学标志(HBVM)的变化.结果治疗组在临床症状,体征改善以及肝功能的改善率明显高于对照组(P＜0.05),两组HBeAg阴转率分别为50.0%和21.9%,两组HBV-DNA的阴转率分别为52.4%和24.4%,治疗组的疗效明显优于对照组(P＜0.05),未见明显不良反应.结论苦参素治疗慢性乙型肝炎疗效确切,价格低廉,无毒副作用,可在临床推广使用.

Comprison of Oxymatrine and Aciclovir in the Treatment of Chronic Hepatitis B.

Objective To survey the clinical therapeutic effectiveness of oxymatrine in the treatment of chronic hepatitis B.Methods 83 patients with chronic hepatitis B were randomly divided into two groups.42 patients in the treatment group were given eath 600mg of oxymatrine im,qd,for 3 month;41 patients in the control group were given each 100mg of aciclovir,per day in 5 divided doses po for 2 month.In the meantime,patients of both groups were subjectal to coventional treatment with hepatinica.Changes in clinical symptoms and signs,liver function tests as well as serological markers of HBVM were compared. Results The improv rate of clinical symptom and lirer function in the treatment were higher than that of coutrol group( P <0.05),HBeAg turned to negative in 50.0% of treatment group compared 21.9% in control group,HBV-DNA turned to negative on 52.4% and 24.4% in the two groups,side effects had not been found. Conclusion Oxymatrine is an effeclive drug in treating chronic hepatitis B,It can be recommended for a wider clinical use.