Aneuploidy in benign seminal vesicle epithelium: an example of the paradox of ploidy studies.

To evaluate if the nuclear enlargement and irregularity of non-neoplastic seminal vesicle epithelium were associated with an abnormal DNA content, 30 seminal vesicles obtained from radical prostatectomies were analyzed by flow cytometry. Twenty-eight (93.3%) of the seminal vesicles showed characteristic diploid histograms, while two (6.7%) showed histograms characteristic of aneuploidy. These results are discussed and other reported examples of aneuploidy in nonmalignant tissues are reviewed.