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Expression of the epidermal growth factor receptor in fetal kidney |
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| Authors: | Paul R. Goodyer Andrey Cybulsky Cynthia Goodyer |
| Affiliation: | (1) Division of Pediatric Nephrology, Montreal Children's Hospital, McGill University, Room E-222, 2300 Tupper Street, H3H 1P3 Montreal, Quebec, Canada;(2) Division of Nephrology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada;(3) Division of Pediatric Endocrinology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada |
| Abstract: | Formation of the human kidney begins at the 6th week of fetal life when the first generations of nephrons are generated from foci of metanephric mesenchyme through contact with the branches of the ureteric bud. This process requires a proliferative burst which must be tightly regulated by local signals. In this report, we review the evidence that the epidermal growth factor receptor molecule is an important arbiter of these events. |
| Keywords: | Epidermal growth factor receptor Fetal kidney Nephron generation |
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