84例肾细胞癌患者MSCT检查的图像分析及相关生物学行为评价

目的分析肾细胞癌患者多层螺旋CT(MSCT)检查的图像及相关生物学行为。方法选取2015年6月~2018年11月我院肾细胞癌患者84例,患者均采取MSCT检查,并行手术治疗,在术中取肾细胞癌组织和相应癌旁正常肾组织标本,以免疫组织化学SP法检测患者肾细胞癌组织和癌旁正常肾组织中Ki-67、缺氧诱导因子-1α(HIF-1α)表达情况,并观察患者MSCT征象(瘤体大小、强化程度、有无坏死、液化、囊变,肿瘤边界清楚与否、有无血管受侵、有无邻近脏器侵犯或远处转移),分析肾细胞癌MSCT征象和Ki-67、HIF-1α表达情况相关性。结果本组术前应用MSCT扫描对肾细胞癌检出率及定性诊断率均为100%;Ki-67、HIF-1α在肾细胞癌组织中表达均高于癌旁正常肾组织(P<0.05);MSCT征象表现为瘤体大小>5cm、强化程度≥20HU、存在坏死、液化、囊变、肿瘤边界不清楚、有血管受侵、产生邻近脏器侵犯或远处转移者Ki-67、HIF-1α表达均高于瘤体大小≤5cm、强化程度<20HU、无坏死、液化、囊变、肿瘤边界清楚、无血管受侵、未产生邻近脏器侵犯或远处转移者(P均<0.05)。结论应用MSCT扫描可对肾细胞癌施行准确术前诊断,且肾细胞癌患者MSCT征象和Ki-67、HIF-1α表达有着密切相关性,能间接反映肿瘤生物学行为,为肾细胞癌诊断、治疗提供有力参考。

Image Analysis and Related Biological Behavior Evaluation of MSCT in 84 Patients with Renal Cell Carcinoma

Objective To analyze the images and related biological behaviors of multislice spiral CT(MSCT) examination in patients with renal cell carcinoma. Methods From June 2015 to November 2018, 84 patients with renal cell carcinoma in our hospital were enrolled. All patients underwent MSCT examination and concurrent surgery. The renal cell carcinoma tissues and corresponding normal renal tissues were taken during the operation to immunize the tissues. Chemical SP method was used to detect the expression of Ki-67 and hypoxia-inducible factor-1α(HIF-1α) in renal cell carcinoma tissues and adjacent normal renal tissues, and to observe the signs of MSCT(tumor size, degree of enhancement, necrosis. liquefaction, cystic change, tumor boundary is clear or not, with or without vascular invasion, presence or absence of adjacent organ invasion or distant metastasis), analysis of renal cell carcinoma MSCT signs and Ki-67, HIF-1α expression correlation. Results The detection rate and qualitative diagnosis rate of renal cell carcinoma were 100% in this group. The expression of Ki-67 and HIF-1α in renal cell carcinoma was higher than that in adjacent normal tissues(P<0.05). MSCT signs are tumor size >5 cm, degree of enhancement ≥20 HU, necrosis, liquefaction, cystic changes, unclear tumor boundaries, vascular invasion, adjacent organ invasion or distant metastasis Ki-67 HIF-1α expression was higher than tumor size ≤5 cm, enhancement degree <20 HU, no necrosis, liquefaction, cystic change, clear tumor boundary, no vascular invasion, no adjacent organ invasion or distant metastasis(P<0.05). Conclusion MSCT scanning can be used for accurate preoperative diagnosis of renal cell carcinoma. The expression of MSCT in renal cell carcinoma is closely related to the expression of Ki-67 and HIF-1α. It can indirectly reflect the biological behavior of the tumor and is a diagnosis of renal cell carcinoma. Treatment provides a powerful reference.