鼻塞持续气道正压通气治疗新生儿呼吸窘迫综合征的临床应用

目的观察鼻塞持续气道正压通气（NCPAP）治疗新生儿呼吸窘迫综合征（NRDS）的疗效。方法对2008年8月～2011年6月本院新生儿重症监护病房收治的60例NRDS进行回顾性分析。观察患儿的临床症状及血气指标在治疗前后的变化。结果 60例患儿中,54例患儿CPAP治疗呼吸困难及低氧血症明显改善,与治疗前比较,差异有统计学意义（P〈0.05）;血气分析pH、PaCO2、PaO2值治疗前后比较,差异有统计学意义（P〈0.05）。6例CPAP治疗无效转为肺表面物质活性＋机械通气。结论早期运用NCPAP可有效的治疗新生儿NRDS,并可减少患儿对机械通气的需要。

Clinical application of nasal continuous positive airway pressure in the treatment of neonatal respiratory distress syndrome

Objective To explore the curative effects of nasal continuous positive airway pressure(NCPAP)ventilation on newborn respiratory distress syndrome(NRDS).Methods Medical records of 60 hospitalized newborns were reviewed.The clinical effects and the blood gas were detected.The results were compared with before and after the treatment with NCPAP.Results The dyspnea and hypoxemia in 54 cases of them has been much improved.the difference was statistically significant(P<0.05);The blood samples PaO2 and pH was increasing while the PaCO2 was decreasing.The difference was statistically significant(P<0.05);6 cases of them were treated with NCPAP had no improvement,but needed the pulmonary surfactant and mechanical ventilation.Conclusion Early NCPAP is significantly effective in treatment with neonatal respiratory distress syndrome and reduce the rate of using traumatic mechanical ventilation.